Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-25T16:41:45.869Z Has data issue: false hasContentIssue false

Sex chromosome configurations in pachytene spermatocytes of an XYY mouse

Published online by Cambridge University Press:  14 April 2009

Charles Tease
Affiliation:
M.R.C. Radiobiology Unit, Chilton, Didcot, Oxon OX11 0RD, U.K.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Karyotypic investigation of a phenotypically normal but sterile male mouse showed the presence of an XYY sex chromosome constitution. The synaptic behaviour of the three sex chromosomes was examined in 65 pachytene cells. The sex chromosomes formed a variety of synaptic configurations: an XYY trivalent (40%); an XY bivalent and Y univalent (38·5%); an X univalent and YY bivalent (13·8%); or X, Y, Y univalence (7·7%). There was considerable variation in the extent of synapsis and some of the associations clearly involved nonhomologous pairing. These observations have been compared with previously published information on chromosome configurations at metaphase I from other XYY males.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1990

References

Berthelsen, J. G., Skakkebaek, N. E., Perboll, O. & Nielsen, J. (1981). Electron microscopical demonstration of the extra Y chromosome in spermatocytes from human XYY males. In Development and Function of Reproductive Organs (ed. Byskov, S. G. and Peters, H.), pp. 328337. Amsterdam: North Holland Elsevier.Google Scholar
Cattanach, B. M. (1967). A test of distributive pairing between two specific non-homologous chromosomes in the mouse. Cytogenetics 6, 6777.CrossRefGoogle ScholarPubMed
Cattanach, B. M. & Pollard, C. E. (1969). An XYY sex-chromosome constitution in the mouse. Cytogenetics 8, 8086.Google Scholar
Chandley, A. C. & Speed, R. M. (1987). Cytological evidence that the Sxr fragment of XY, Sxr mice pairs homologously at meiotic prophase with the proximal testis-determining region. Chromosoma (Berlin) 95, 345349.Google Scholar
Das, R. K. & Behera, A. K. (1984). A 39, X0/40, XY/41, XYY mosaic male mouse. Cytogenetics and Cell Genetics 38, 138141.CrossRefGoogle Scholar
Evans, E. P., Beechey, C. V. & Burtenshaw, M. D. (1978). Meiosis and fertility in XYY mice. Cytogenetics and Cell Genetics 20, 249263.CrossRefGoogle ScholarPubMed
Evans, E. P., Breckon, G. & Ford, C. E. (1964). An air-drying method for meiotic preparations for mammalian testes. Cytogenetics 3, 289294.CrossRefGoogle ScholarPubMed
Evans, E. P., Ford, C. E. & Searle, A. G. (1969). A 39 X0/41 XYY mosaic mouse. Cytogenetics 8, 8796.Google Scholar
Ford, C. E. (1970). The population Cytogenetics of other mammalian species. In Human Population Cytogenetics (ed. Jacobs, P. A., Price, W. H. and Law, P.), pp. 229239. Edinburgh: Edinburgh University Press.Google Scholar
Gropp, A. (1982). Value of an animal model for trisomy. Virchow's Archiv (Pathol. Anat.) 395, 117131.CrossRefGoogle ScholarPubMed
Hale, D. W. & Greenbaum, I. F. (1986). Spontaneous occurrence of XYY primary spermatocytes in the Sitka deer mouse. Journal of Heredity 77, 131132.CrossRefGoogle ScholarPubMed
Jacobs, P., Hassold, T., Harvey, J. & Kristen, M. (1989). The origin of sex chromosome aneuploidy. In Molecular and Cytogenetic Studies of Non-disjunction (ed. Hassold, T. J. and Epstein, C. J.), pp. 135151. New York: Alan R. Liss.Google Scholar
Palmer, S. J., Mahadevaiah, S. K. & Burgoyne, P. S. (1990) XYY spermatogenesis in X0/XY/XYY mosaic mice. Cytogenetics and Cell Genetics (in press).CrossRefGoogle Scholar
Rathenberg, R. & Muller, D. (1973). X and Y chromosome pairing and disjunction in a male mouse with an XYY sex-chromosome constitution. Cytogenetics and Cell Genetics 12, 8792.Google Scholar
Tease, C. & Cattanach, B. M. (1989). Sex chromosome pairing patterns in male mice of novel Sxr genotypes. Chromosoma (Berlin) 97, 390395.CrossRefGoogle ScholarPubMed
Tres, L. (1977). Extensive pairing of the XY bivalent in mouse spermatocytes as visualized by whole-mount electron microscopy. Journal of Cell Science 25, 115.Google Scholar