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Segregation ratios within Segregation Distorter lines of Drosophila melanogaster conform to a beta-binomial distribution

Published online by Cambridge University Press:  14 April 2009

Cecil B. Sharp  and
Arthur J. Hilliker
Cecil B. Sharp
Affiliation:
Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Arthur J. Hilliker
Affiliation:
Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Segregation Distorter (SD) chromosomes are preferentially recovered from SD/SD+ males due to the dysfunction of sperm bearing the SD+ chromosome. The proportion of offspring bearing the SD chromosome is given the symbol k. The nature of the frequency distribution of k was examined by comparing observed k distributions produced by six different SD chromosomes, each with a different mean, with k distributions predicted by two different statistical models. The first model was one where the k of all males with a given SD chromosome were considered to be equal prior to the determination of those gametes which produce viable zygotes. In this model the only source of variation of k would be binomial sampling. The results rigorously demonstrated for the first time that the observed k distributions did not fit the prediction that the only source of variation was binomial sampling. The next model tested was that the prior distribution of segregation ratios conformed to a beta distribution, such that the distribution of k would be a beta-binomial distribution. The predicted distributions of this model did not differ significantly from the observed distributions of k in five of the six cases examined. The sixth case probably failed to fit a beta-binomial distribution due to a major segregating modifier. The demonstration that the prior distribution of segregation ratios of SD lines can generally be approximated with a beta distribution is crucial for the biometrical analysis of segregation distortion.

Type
Research Article
Information
Genetics Research , Volume 55 , Issue 3 , June 1990 , pp. 165 - 170
Copyright
Copyright © Cambridge University Press 1990

References

Brittnacher, J. G. & Ganetzky, B. (1983). On the components of segregation distortion in Drosophila melanogaster. II. Deletion mapping and dosage analysis of the SD locus. Genetics 103, 659–673.CrossRefGoogle ScholarPubMed
Brittnacher, J. G. & Ganetzky, B. (1984). On the components of segregation distortion in Drosophila melanogaster. III. Nature of enhancer of SD. Genetics 107, 423–434.CrossRefGoogle ScholarPubMed
Edwards, A. W. F. (1958). An analysis of Geissler's data on the human sex ratio. Annals of Human Genetics 23, 6–15.CrossRefGoogle ScholarPubMed
Edwards, A. W. F. & Fraccaro, M. (1958). The sex distribution in the offspring of 5477 Swedish ministers of religion, 1585–1920. Hereditas 44, 447–450.Google Scholar
Ganetzky, B. (1977). On the components of segregation distortion in Drosophila melanogaster. Genetics 86, 321–355.CrossRefGoogle ScholarPubMed
Geissler, A. (1889). Beiträge zur Frage des Geschlechtsverhältnisses der Geborenen. Z. K. Sächs. Stat. Bureaus 35, 1–24.Google Scholar
Hartl, D. L. (1974). Genetic dissection of segregation distortion. I. Suicide combinations of SD genes. Genetics 76, 477–486.CrossRefGoogle ScholarPubMed
Hiraizumi, Y. & Crow, J. F. (1960). Heterozygous effects on viability, fertility, rate of development and longevity of Drosophila chromosomes that are lethal when homozygous. Genetics 45, 1071–1084.CrossRefGoogle ScholarPubMed
Hiraizumi, Y., Martin, D. W. & Eckstrand, I. A. (1980). A modified model of segregation distortion in Drosophila melanogaster. Genetics 95, 693–706.CrossRefGoogle ScholarPubMed
Lyttle, T. W., Brittnacher, J. G. & Ganetzky, B. (1986). Detection of Rsp and modifier variation in the meiotic drive system Segregation Distorter (SD) of Drosophila melanogaster. Genetics 114, 183–202.CrossRefGoogle ScholarPubMed
Martin, D. W. & Hiraizumi, Y. (1979). On the models of segregation distortion in Drosophila melanogaster. Genetics 93, 423–435.CrossRefGoogle ScholarPubMed
Miklos, G. L. G. & Smith-White, S. (1971). An analysis of the instability of segregation-distorter in Drosophila melanogaster. Genetics 67, 305–317.CrossRefGoogle ScholarPubMed
Nicoletti, B. (1968). Il controllo genetico della meiosi. Atti. Associazione Genetica Italiana 13, 1–71.Google Scholar
Sandler, L. & Hiraizumi, Y. (1960). Meiotic drive in natural populations of Drosophila melanogaster. IV. Instability at the segregation-distorter locus. Genetics 45, 1269–1287.CrossRefGoogle ScholarPubMed
Sandler, L. & Hiraizumi, Y. (1961). Meiotic drive in natural populations of Drosophila melanogaster. VIII. A heritable ageing effect on the phenomenon of segregation distortion. Canadian Journal of Genetics and Cytology 3, 34–36.CrossRefGoogle Scholar
Sandler, L., Hiraizumi, Y. & Sandler, I. (1959). Meiotic drive in natural populations of Drosophila melanogaster. I. The cytogenetic basis of segregation-distortion. Genetics 44, 233–250.CrossRefGoogle ScholarPubMed
Sharp, C. B. & Hilliker, A. J. (1986). Measuring segregation distortion in Drosophila melanogaster. Canadian Journal of Genetics and Cytology 28, 395–400.CrossRefGoogle Scholar
Sharp, C. B. & Hilliker, A. J. (1987). The k-probit transformation and segregation distortion. Drosophila Information Service 66, 127–128.Google Scholar
Sharp, C. B., Hilliker, A. J. & Holm, D. G. (1985). Further characterization of genetic elements associated with the segregation distortion phenomenon in Drosophila melanogaster. Genetics 110, 671–688.CrossRefGoogle ScholarPubMed
Skellam, J. G. (1948). A probability distribution derived from the binomial distribution by regarding the probability of success as variable between the sets of trials. Journal of the Royal Statistical Society B 10, 257–261.Google Scholar
Temin, R. G. & Marthas, M. (1984). Factors influencing the effect of segregation distortion in natural populations of Drosophila melanogaster. Genetics 107, 375–393.CrossRefGoogle ScholarPubMed
Tokuyasu, K. T., Peacock, W. J. & Hardy, R. W. (1977). Dynamics of spermiogenesis in Drosophila melanogaster. VII. Effects of segregation distorter (SD) chromosome. Journal of Ultrastructure Research 58, 96–107.CrossRefGoogle ScholarPubMed
Wu, C.-I., Lyttle, T. W., Wu, M. L. & Lin, G. F. (1988). Association between a satellite DNA sequence and the Responder of segregation distortion in D. melanogaster. Cell 54, 179–189.CrossRefGoogle ScholarPubMed