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A search for histocompatibility differences between irradiated sublines of inbred mice

Published online by Cambridge University Press:  14 April 2009

J. Godfrey  and
A. G. Searle
J. Godfrey
Affiliation:
Medical Research Council, Radiobiological Research Unit, Harwell, Berkshire, England
A. G. Searle
Affiliation:
Medical Research Council, Radiobiological Research Unit, Harwell, Berkshire, England
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(1) A tail-skin grafting method was used to test for histocompatibility differences between members of thirteen sublines of C3H inbred mice, kept in a 1 r./night gamma radiation field for twelve generations, on the average, and separated from each other by about thirty-four generations.

(2) No homograft rejections occurred, so there was no evidence to suggest that mutations at histocompatibility loci had taken place in any of these sublines. Calculations show that this finding does not conflict with the idea that a fairly large number of loci are involved, having mutation rates similar to those already known in the mouse.

Type
Research Article
Information
Genetics Research , Volume 4 , Issue 1 , February 1963 , pp. 21 - 29
Copyright
Copyright © Cambridge University Press 1963

References

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