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Role of transposable elements in age-related genomic instability

Published online by Cambridge University Press:  01 June 1997

A. G. NIKITIN  and
R. J. SHMOOKLER REIS
A. G. NIKITIN
Affiliation:
University of Arkansas for Medical Sciences, Departments of Medicine and Biochemistry/Molecular Biology, and J. L. McClellan Veterans Medical Center, Research – 151, Little Rock, AR 72205, USA
R. J. SHMOOKLER REIS
Affiliation:
University of Arkansas for Medical Sciences, Departments of Medicine and Biochemistry/Molecular Biology, and J. L. McClellan Veterans Medical Center, Research – 151, Little Rock, AR 72205, USA
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Abstract

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Genetic instability is associated with aging in many species. One of the initiating factors for genetic instability is the movement of transposable elements (TEs), which occur in all prokaryotic and eukaryotic organisms. The hypothesis that TEs could be involved in the aging process is discussed and the correlation between aging and activity of TEs is analysed in a variety of biological systems.

Type
Research Article
Information
Genetics Research , Volume 69 , Issue 3 , June 1997 , pp. 183 - 195
Copyright
© 1997 Cambridge University Press