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A Revised Nomenclature for the Mouse Transferrin Locus

Published online by Cambridge University Press:  14 April 2009

B. L. Cohen  and
D. C. Shreffler
B. L. Cohen
Affiliation:
Department of Genetics, The University, Glasgow
D. C. Shreffler
Affiliation:
Division of Biology, California Institute of Technology, Pasadena
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In independent investigations, reported almost simultaneously (Cohen, 1960; Shreffler, 1960), the authors have described a protein variant system in the serum of mice, involving an electrophoretic difference in the iron-binding beta-globulin component, transferrin, and have shown the difference to be genetically determined by a pair of co-dominant alleles at a single locus. Both reports introduced the same gene symbol, Trf, for this locus, but in one, letter designations were used (Cohen, 1960), making the allele symbols TrfA and TrfB, and the three phenotypes TrfA, TrfAB and TrfB, while in the other, number designations were used (Shreffler, 1960), with the corresponding symbols Trf1, Trf2, Trf-1, Trf-1·2 and Trf-2. To avoid confusion in future reference to this locus, due to the two differing systems of nomenclature, the authors have agreed upon the revised nomenclature proposed in this communication.

Type
Short Notes
Information
Genetics Research , Volume 2 , Issue 2 , July 1961 , pp. 306 - 308
Copyright
Copyright © Cambridge University Press 1961

References

REFERENCES

Cohen, B. L. (1960). Genetics of plasma transferring in the mouse. Genet. Res., 1, 431–438.CrossRefGoogle Scholar
Committee on Standardized Genetic Nomenclature for the Mouse (1959). Mouse News Letter, No. 20, p. 1.Google Scholar
Russell, E. S. & Gerald, P. S. (1958). Inherited electrophoretic haemoglobin patterns among 20 inbred strains of mice. Science, 128, 1569–1570.CrossRefGoogle ScholarPubMed
Shreffler, D. C. (1960). Genetic control of serum transferrin type in mice. Proc. not. Acad. Sci., Wash., 46, 1378–1384.CrossRefGoogle ScholarPubMed