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Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR

Published online by Cambridge University Press:  01 April 1998

DIETER WEICHENHAN ,
BÄRBEL KUNZE ,
WALTHER TRAUT  and
HEINZ WINKING
DIETER WEICHENHAN
Affiliation:
Institut für Biologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
BÄRBEL KUNZE
Affiliation:
Institut für Biologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
WALTHER TRAUT
Affiliation:
Institut für Biologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
HEINZ WINKING
Affiliation:
Institut für Biologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
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Abstract

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The house mouse, Mus musculus, harbours a variable cluster of long-range repeats in chromosome 1. As shown in previous studies, some high-copy clusters such as the MUT cluster are cytogenetically apparent as a homogeneously staining region (HSR) and are associated with a distortion of the Mendelian recovery ratio when transmitted by heterozygous females. The effect is caused by a decreased viability of +/+ embryos. It is compensated by maternal or paternal MUT. In this study, a deletion derivative of MUT, MUTdel, shows normal transmission ratios and no compensating capability. In this respect, MUTdel behaves like a wild-type cluster. Hence, both properties – transmission ratio distortion and compensating capability – map to the deleted region. The deletion comprises three-quarters of the MUT HSR and does not extend to the nearest markers adjacent to the HSR.

Type
Research Article
Information
Genetics Research , Volume 71 , Issue 2 , April 1998 , pp. 119 - 125
Copyright
© 1998 Cambridge University Press