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Recombination between the t6 complex and linked loci in the house mouse

Published online by Cambridge University Press:  14 April 2009

Joseph H. Nadeau ,
Sandra J. Phillips  and
Igor K. Egorov
Joseph H. Nadeau
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
Sandra J. Phillips
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
Igor K. Egorov
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
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Summary

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Recombination between the t6 complex, three allozyme-encoding loci, two antigen-encoding loci, and four molecular markers was studied. The allozyme-encoding loci were complement component-3 (C-3), kidney catalase (Ce-2), and glyoxalase-1 (Glo-1); the antigen-encoding loci were the H-2 Class I genes H-2K and H-2D; the four molecular markers were Tu66, an α-globin pseudogene (Hba-4ps), an unidentified H-2 Class I gene, and the H-2 Class II gene I-Aβ. The latter six loci were used as markers for the t complex. Recombination was detected between Glo-1, Ce-2 and C-3, but not between the markers for the t complex Tu66, Hba-4ps, and the H-2 loci. These data indicate that Ce-2 and C-3 are located outside the t6 complex, while the latter are located within. These data also indicate that the telomeric boundary of the t6 complex is located between H-2 and Ce-2. Recently published studies have shown that complete gametic disequilibrium exists between the t complex and loci located centromeric to the H-2 - Ce-2 interval, while disequilibrium was not detected between loci located telomeric to this interval. Loci included within the region of recombination suppression are also those in disequilibrium with the t complex. As a result, recombination suppression probably resulting from chromosomal rearrangements associated with the t complex appears to be a sufficient explanation for the gametic disequilibrium observed between certain loci and the t complex.

Type
Research Article
Information
Genetics Research , Volume 45 , Issue 3 , June 1985 , pp. 251 - 264
Copyright
Copyright © Cambridge University Press 1985

References

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