Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-24T11:50:43.716Z Has data issue: false hasContentIssue false
  • English
  • Français

QTL-based evidence for the role of epistasis in evolution

Published online by Cambridge University Press:  15 December 2005

RUSSELL L. MALMBERG  and
RODNEY MAURICIO
RUSSELL L. MALMBERG
Affiliation:
Department of Plant Biology, University of Georgia, Athens, GA 30602-7271, USA
RODNEY MAURICIO
Affiliation:
Department of Genetics, University of Georgia, Athens, GA 30602-7223, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The extent to which epistasis contributes to adaptation and speciation has been a controversial topic in evolutionary genetics. One experimental approach to study epistasis is based on quantitative trait locus (QTL) mapping using molecular markers. Comparisons can be made among all possible pair-wise combinations of the markers, irrespective of whether an additive QTL is associated with a marker; several software packages have been developed that facilitate this. We review several examples of using this approach to identify epistatic QTLs for traits of evolutionary or ecological interest. While there is variability in the results, the number of epistatic QTL interactions is often greater than or equal to the number of additive QTLs. The magnitude of epistatic effects can be larger than the additive effects. Thus, epistatic interactions seem to be an important part of natural genetic variation. Future studies of epistatic QTLs could lead to descriptions of the genetic networks underlying variation for fitness-related traits.

Type
Minireview
Information
Genetics Research , Volume 86 , Issue 2 , October 2005 , pp. 89 - 95
Copyright
© 2005 Cambridge University Press