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Probability of identical monomorphism in related species

Published online by Cambridge University Press:  14 April 2009

Masatoshi Nei  and
Wen-Hsiung Li
Masatoshi Nei
Affiliation:
Center for Demographic and Population Genetics, University of Texas at Houston, Texas 77025
Wen-Hsiung Li
Affiliation:
Center for Demographic and Population Genetics, University of Texas at Houston, Texas 77025
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Summary

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A mathematical method for evaluating the probability that a locus is monomorphic for the same allele in related species is developed under the neutral mutation hypothesis. A formula for the proportion of identically monomorphic loci in related species is also worked out. The results of the application of this method to Drosophila data do not support Prakash & Lewontin's (1968) contention that the strong association between gene arrangements (inversion chromosomes) and alleles at protein loci is evidence of coadaptation of genes in the inverted segment of chromosomes. Similarly, unlike Haigh & Maynard Smith's (1972) contention, the monomorphism of the haemoglobin α chain locus in man can be accommodated with the neutral mutation hypothesis without invoking the bottleneck effect.

Type
Research Article
Information
Genetics Research , Volume 26 , Issue 1 , August 1975 , pp. 31 - 43
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Ayala, F. J. & Tracey, M. L. (1974). Genetic differentiation within and between species of the Drosophila willistoni group. Proceedings of the National Academy of Sciences 71, 999–1003.CrossRefGoogle ScholarPubMed
Crow, J. F. & Kimura, M. (1970). An Introduction to Population Genetics Theory. New York: Harper and Row.Google Scholar
Dobzhansky, Th. (1971). Evolutionary oscillations in Drosophila pseudoobscura. Ecological Genetics (ed. Creed, R.), pp. 109–133. Oxford: Blackwell.CrossRefGoogle Scholar
Haigh, J. & Maynard Smith, J. (1972). Population size and protein variation in man. Genetical Research 19, 73–89.CrossRefGoogle ScholarPubMed
Harris, H. & Hopkinson, D. A. (1972). Average heterozygosity per locus in man: an estimate based on the incidence of enzyme polymorphisms. Annals of Human Genetics 36, 9–20.CrossRefGoogle Scholar
Hill, W. G. & Robertson, A. (1968). Linkage disequilibrium in finite populations. Theoretical & Applied Genetics 38, 226–231.CrossRefGoogle ScholarPubMed
Hunt, L. T., Sochard, M. R. & Dayhoff, M. O. (1972). Mutations in human genes: abnormal hemoglobins and myoglobins. Atlas of Protein Sequence and Structure, vol. 5 (ed. Dayhoff, M. O.), pp. 67–87. National Biomedical Research Foundation, Washington, D.C.Google Scholar
Kimura, M. (1968). Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genetical Research 11, 247–269.CrossRefGoogle Scholar
Kimura, M. (1971). Theoretical foundations of population genetics at the molecular level. Theoretical Population Biology 2, 174–208.CrossRefGoogle ScholarPubMed
Kimura, M. & Crow, J. F. (1964). The number of alleles that can be maintained in a finite population. Genetics 49, 725–738.CrossRefGoogle Scholar
Kimura, M. & Ohta, T. (1971). Theoretical Aspects of Population Genetics. Princeton, New Jersey: Princeton University Press.Google ScholarPubMed
King, M. & Wilson, A. C. (1975). Evolution at two levels: molecular similarities and biological differences between humans and chimpanzees. Science 188, 107–116.CrossRefGoogle Scholar
Kojima, K., Gillespie, J. & Tobari, Y. N. (1970). A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymes. Biochemical Genetics 4, 627–637.CrossRefGoogle ScholarPubMed
Mukai, T., Mettler, L. E. & Chigusa, S. I. (1971). Linkage disequilibrium in a local population of Drosophila melanogaster. Proceedings of the National Academy of Sciences 68, 1065–1069.CrossRefGoogle Scholar
Nair, P. S. & Brncic, D. (1971). Allelic variations within identical chromosomal inversions. American Naturalist 105, 291–294.CrossRefGoogle Scholar
Neel, J. V. (1970). Lessons from a ‘primitive’ people. Science 170, 815–822.CrossRefGoogle ScholarPubMed
Nei, M. (1970). Effective size of human populations. American Journal of Human Genetics 22, 694–696.Google ScholarPubMed
Nei, M. (1975). Molecular Population Genetics and Evolution. Amsterdam: North-Holland Publishing Company.Google ScholarPubMed
Nei, M., Maruyama, T. & Chakraborty, R. (1975). The bottleneck effect and genetic variability in populations. Evolution 29, 1–10.CrossRefGoogle ScholarPubMed
Nei, M. & Roychoudhury, A. K. (1974). Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids. American Journal of Human Genetics 26, 421–443.Google ScholarPubMed
Ohta, T. & Kimura, M. (1973). A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genetical Research 22, 201–204.CrossRefGoogle Scholar
Prakash, S. (1969). Genic variation in a natural population of Drosophila persimilis. Proceedings of the National Academy of Sciences 62, 778–784.CrossRefGoogle Scholar
Prakash, S. & Lewontin, R. C. (1968). A molecular approach to the study of genie heterozygosity in natural populations. III. Direct evidence of coadaptation in gene arrangements of Drosophila. Proceedings of the National Academy of Sciences 59, 398–405.CrossRefGoogle Scholar
Prakash, S., Lewontin, R. C. & Hubby, J. L. (1969). A molecular approach to the study of genie heterozygosity in natural populations. IV. Patterns of genic variation in central, marginal and isolated populations of Drosophila pseudoobscura. Genetics 61, 841–858.CrossRefGoogle Scholar
Sarich, V. M. & Wilson, A. C. (1967). Immunological time scale for hominid evolution. Science 158, 1200–1203.CrossRefGoogle ScholarPubMed
Spiess, E. B. (1965). A discovery and rediscovery of third chromosome arrangements in Drosophila persimilis. American Naturalist 99, 423–425.CrossRefGoogle Scholar
Sved, J. A. (1968). The stability of linked systems of loci with a small population size. Genetics 59, 543–563.CrossRefGoogle ScholarPubMed
Wilson, A. C. & Sarich, V. M. (1969). A molecular time scale for human evolution. Proceedings of the National Academy of Sciences 63, 1088–1093.CrossRefGoogle ScholarPubMed