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Probability of identical monomorphism in related species

Published online by Cambridge University Press:  14 April 2009

Masatoshi Nei  and
Wen-Hsiung Li
Masatoshi Nei
Affiliation:
Center for Demographic and Population Genetics, University of Texas at Houston, Texas 77025
Wen-Hsiung Li
Affiliation:
Center for Demographic and Population Genetics, University of Texas at Houston, Texas 77025
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Summary

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A mathematical method for evaluating the probability that a locus is monomorphic for the same allele in related species is developed under the neutral mutation hypothesis. A formula for the proportion of identically monomorphic loci in related species is also worked out. The results of the application of this method to Drosophila data do not support Prakash & Lewontin's (1968) contention that the strong association between gene arrangements (inversion chromosomes) and alleles at protein loci is evidence of coadaptation of genes in the inverted segment of chromosomes. Similarly, unlike Haigh & Maynard Smith's (1972) contention, the monomorphism of the haemoglobin α chain locus in man can be accommodated with the neutral mutation hypothesis without invoking the bottleneck effect.

Type
Research Article
Information
Genetics Research , Volume 26 , Issue 1 , August 1975 , pp. 31 - 43
Copyright
Copyright © Cambridge University Press 1975

References

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