Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-04T19:07:28.905Z Has data issue: false hasContentIssue false
  • English
  • Français

A presumed deletion covering the W and Ph loci of the mouse

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon ,
P. H. Glenister ,
J. F. Loutit ,
E. P. Evans  and
J. Peters
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
P. H. Glenister
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
J. F. Loutit
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
E. P. Evans
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England
J. Peters
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 0RD, England

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A new allele at the W-locus ( W19H), found in a mutagenesis experiment in which females were irradiated, involves a presumed deletion. The deletion covers the Ph locus (which forms part of a gene complex with the W, Ph and Rw loci), and the locus of a recessive lethal 2 cM distal to W. It does not extend distally to the bl locus; nor does it involve the Rw locus, W19H/Rw compounds being viable and fertile. Thus, the length of the deletion is 2–7 cM. The non-involvement of Rw shows that, in the gene triplet Rw, W, Ph, Rw must lie proximal to W and Ph, whose relative position remains unknown. Heteozygotes for W19H are not anaemic, show only minimal white spotting and no pigment dilution; they thus resemble heterozygotes for the original W mutant allele and differ from W/Ph trans heterozygotes, which have extensive white spotting. In addition W19H heterozygotes may be small and runted, many are believed to die prenatally, and some in the nest. Their radiosensitivity is increased. Homozygotes die at the pre-implantation stage.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 2 , October 1984 , pp. 161 - 168
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Geissler, E. N., McFarland, E. C. & Russell, E. S. (1981). Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: A description of ten new W alleles. Genetics 97, 337–361.CrossRefGoogle ScholarPubMed
Grüneberg, H. & Truslove, G. M. (1960). Two closely linked genes in the mouse. Genetical Research 1, 69–90.CrossRefGoogle Scholar
Kacser, H. & Burns, J. A. (1981). The molecular basis of dominance. Genetics 97, 639–666.CrossRefGoogle ScholarPubMed
Loutit, J. F. & Cattanach, B. M. (1983). Haematopoietic role for Patch (Ph) revealed by new W mutant (W ct) in mice. Genetical Research 42, 29–39.CrossRefGoogle Scholar
Loutit, J. F., Corp, M. J. & Adams, P. J. V. (1982). Radiosensitivity of mice with mutation at loci W, Ph. International Journal of Radiation Biology 42, 93–97.Google ScholarPubMed
Lyon, M. F. & Bechtol, K. B. (1977). Derivation of mutant t–haplotypes of the mouse by presumed duplication or deletion. Genetical Research 30, 63–76.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Glenister, P. H. (1982). A new allele sash (W sh) at the W-locus and a spontaneous recessive lethal in mice. Genetical Research 39, 315–322.CrossRefGoogle Scholar
Lyon, M. F., Phillips, R. J. S. & Fisher, G. (1979). Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutation Research 63, 161–173.CrossRefGoogle ScholarPubMed
Russell, E. S. (1979). Hereditary anaemias of the mouse: a review for geneticists. Advances in Genetics 20, 357–459.CrossRefGoogle Scholar
Russell, L. B. (1971). Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutation Research 11, 107–123.CrossRefGoogle Scholar
Russell, L. B. (1983). Qualitative analysis of mouse specific-locus mutations: information on genetic organization, gene expression, and the chromosomal nature of induced lesions. In Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk (ed. de Serres, P. J. and Sheridan, W.), pp. 241–258. New York: Plenum Pess.CrossRefGoogle Scholar
Searle, A. G. (1981). Numerical variants and structural rearrangements. In Genetic Variants and Strains of the Laboratory Molise, chap. 7.1 (ed. Green, M. C.), pp. 324–357. Stuttgart: Gustav Fischer.Google Scholar
Searle, A. G. & Truslove, G. M. (1970). A gene triplet in the mouse. Genetical Research 15, 227–235.CrossRefGoogle ScholarPubMed