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The power of the transmission disequilibrium test (TDT) with both case–parent and control–parent trios

Published online by Cambridge University Press:  01 February 2002

HONG-WEN DENG  and
WEI-MIN CHEN
HONG-WEN DENG
Affiliation:
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, ChangSha, Hunan 410081, P. R. China Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N. 30th Street, Suite 6787, Omaha, NE 68131, USA
WEI-MIN CHEN
Affiliation:
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N. 30th Street, Suite 6787, Omaha, NE 68131, USA
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Abstract

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The transmission disequilibrium test (TDT) customarily uses affected children and their parents (often case–parent trios, TDTD). Control–parent trios are necessary to guard against spurious significant results due to segregation distortion but are not generally utilized in the identification of disease susceptibility loci (DSL). Controls are often easy to recruit and the TDT can easily be extended to include control–parent trios into the analyses with unrelated case–parent trios. We present an extension of the TDT (TDTDC) that incorporates unrelated cases and controls and their parents into a single analysis. We develop a simple and accurate analytical method for computing the statistical power of various TDT (e.g. the TDTD, TDTDC, TDTDC and TDTC that employ control–parent trios only) under any genetic model. We investigated the power of these TDT, and particularly compared the relative power of the TDTD and TDTDC. We found that the TDTDC is almost always more powerful than the TDTC and TDTD. The relative power of the TDTDC and TDTD depends largely upon a number of parameters identified in the study. This study provides a basis for efficient use of control–parent trios in DSL identification.

Type
Research Article
Information
Genetics Research , Volume 78 , Issue 3 , December 2001 , pp. 289 - 302
Copyright
© 2001 Cambridge University Press