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Postmeiotic segregation as a source of mosaics in diploid organisms

Published online by Cambridge University Press:  14 April 2009

John F. Leslie  and
Ward B. Watt
John F. Leslie
Affiliation:
Department of Biological Sciences, Stanford University, Stanford, California 94305-2493, U.S.A.
Ward B. Watt
Affiliation:
Department of Biological Sciences, Stanford University, Stanford, California 94305-2493, U.S.A.
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Summary

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Postmeiotic segregation (PMS) of genetic variants occurs when a DNA heteroduplex formed during meiotic recombination goes undetected by repair enzymes and is transmitted unresolved to the meiotic products. PMS provides an alternative explanation for the origin of mosaics now attributed to half-chromatid mutation. In multicellular diploid eukaryotes, PMS could result in mosaic individuals with unusual migration patterns for proteins studied by gel electrophoresis. If the gonade were mosaic, complex progenies containing as many as six phenotypic classes at a single locus could be produced.

Type
Short Paper
Information
Genetics Research , Volume 44 , Issue 2 , October 1984 , pp. 225 - 229
Copyright
Copyright © Cambridge University Press 1984

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