Hostname: page-component-5cf477f64f-2wr7h Total loading time: 0 Render date: 2025-04-06T08:53:06.588Z Has data issue: false hasContentIssue false
  • English
  • Français

Physiological genetics of melanotic tumours in Drosophila melanogaster: VIII. The role of choline in the expression of the tumour gene tu bw and of its suppressor, su-tu

Published online by Cambridge University Press:  14 April 2009

John C. Sparrow  and
James H. Sang
John C. Sparrow
Affiliation:
Department of Biology, University of York, Heslington, York
James H. Sang
Affiliation:
School of Biological Sciences, University of Sussex, Brighton, England
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The melanotic tumour gene tu bw of Drosophila melanogaster has a specific suppressor su-tu. The genotypes tu bw; +su-tu and tu bw; su-tu show opposite responses, as measured by tumour penetrance, to increasing choline levels in the defined axenic medium. The three major metabolic functions of choline have been examined using additions to the axenic medium to determine which biochemical pathway(s) are different in the two genotypes. It is concluded that the opposite strain responses are due to changes in the pattern of phospholipid synthesis, and that the gene product of the su-tu gene probably functions in this area of metabolism.

Type
Research Article
Information
Genetics Research , Volume 24 , Issue 2 , October 1974 , pp. 215 - 227
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Bieber, L. L. & Rottman, F. M. (1973). Incorporation of the methyl group of methionine into lipids and RNA by Musca domestica larvae. Insect Biochemistry 3, 217–221.CrossRefGoogle Scholar
Bridges, R. G. (1972). Choline metabolism in insects. Advances in Insect Physiology 9, 51–110.CrossRefGoogle Scholar
Bridges, R. G., Ricketts, J. & Cox, J. T. (1965). The incorporation of analogues of choline into the phospholipids of the housefly Musca domestica. Journal of Insect Physiology 16, 579–593.CrossRefGoogle Scholar
Bryant, P. J. (1967). Effects of hormonally active materials on gene action in Drosophila. D.Phil. Thesis, University of Sussex.Google Scholar
Bryant, P. J. & Sang, J. H. (1969). Physiological genetics of melanotic tumours in Drosophila melanogaster. VI. The tumorigenic effects of juvenile hormone-like substances. Genetics 62, 521–536.CrossRefGoogle ScholarPubMed
Burnet, B. (1966). Allelism of tumour genes. Drosophila Information Service 41, 161.Google Scholar
Burnet, B. & Sang, J. H. (1964). Physiological genetics of melanotic tumours in Drosophila melanogaster. II. The genetic basis of response to tumorigenic treatments in the tuk and tu bw; st su-tu strains. Genetics 49, 223–235.CrossRefGoogle Scholar
Burnet, B. & Sang, J. H. (1968). Physiological genetics of melanotic tumours in Drosophila melanogaster. V. Amino acid metabolism and tumour formation in the tu bw; st su-tu strain. Genetics 59, 211–255.CrossRefGoogle Scholar
Dadd, R. H. (1970). Arthropod Nutrition in Chemical Zoology (ed. Florkin, M. and Scheer, B. T.), pp. 35–95. Academic Press.CrossRefGoogle Scholar
Dwivedy, A. K. & Bridges, R. G. (1973). The effects of dietary changes on the phospholipid composition of the haemolymph lipoproteins of the larvae of the housefly Musca domestica. Journal of Insect Physiology 19, 559–576.CrossRefGoogle ScholarPubMed
Geer, B. W., Dolph, W. W., Maguire, J. A. & Dates, R. J. (1971). The metabolism of dietary carnitine in Drosophila melanogaster. Journal of Experimental Zoology 176, 445–460.CrossRefGoogle Scholar
Geer, B. W. & Vovis, G. F. (1965). The effects of choline and related compounds on the growth and development of Drosophila melanogaster. Journal of Experimental Zoology 158, 223–236.CrossRefGoogle ScholarPubMed
Gilmour, D. (1961). The Biochemistry of Insects. Academic Press.Google Scholar
Glass, B. (1954). New mutants: Report. Drosophila Information Service 28, 74.Google Scholar
Glass, B. (1957). In pursuit of a gene. Science 126, 683–689.CrossRefGoogle ScholarPubMed
Hodgson, E., Smith, E. & Snyder, K. D. (1972). Nutrition and metabolism of certain methyl-containing compounds in insects. In Insect and Mite Nutrition (ed. Rodriguez, J. G.), pp. 453–470. Amsterdam and London: North Holland Publishing Co.Google Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster Carnegie Institute of Washington Publication, no. 627.Google Scholar
Lord, K. A. & Potter, C. (1951). Studies on the mechanism of action of organophosphorus compounds with particular reference to their anti-esterase activity. Annals of Applied Biology 38, 495.CrossRefGoogle Scholar
Macintosh, F., Birks, R. & Sastry, R. (1956). Pharmacological inhibition of acetylcholine synthesis. Nature 178, 1181.CrossRefGoogle Scholar
Plaine, H. L. & Glass, B. (1955). Influence of tryptophan and related compounds upon the action of a specific gene and the induction of melanotic tumours in Drosophila melanogaster. Journal of Genetics 53, 244–261.CrossRefGoogle Scholar
Rizki, T. M. (1957). Tumour formation in relation to metamorphosis in Drosophila melanogaster. Journal of Morphology 100, 459–472.CrossRefGoogle Scholar
Rizki, T. M. (1960). Melanotic tumour formation in Drosophila. Journal of Morphology 106, 147–157.CrossRefGoogle Scholar
Rizki, T. M. (1962). Experimental analysis of hemocyte morphology in insects. American Zoologist 2, 247–256.CrossRefGoogle Scholar
Sang, J. H. (1956). The quantitative nutritional requirements of Drosophila melanogaster. Journal of Experimental Biology 33, 45–72.CrossRefGoogle Scholar
Sang, J. H. (1966). Clearing Drosophila adults. Drosophila Information Service 41, 200.Google Scholar
Sang, J. H. (1968). Biochemical basis of hereditary melanotic tumours in Drosophila. National Cancer Institute Monograph 31, 291–301.Google Scholar
Sang, J. H. & Burnet, B. (1963). Physiological genetics of melanotic tumours in Drosophila melanogaster. I. The effects of nutrient balance on tumour penetrance in the tuk strain. Genetics 48, 235–253.CrossRefGoogle Scholar
Sang, J. H. & Burnet, B. (1967). Physiological genetics of melanotic tumours in Drosophila melanogaster. IV. Gene-environment interactions of tu bw with different third chromosome backgrounds. Genetics 56, 743–754.CrossRefGoogle Scholar
Sparrow, J. C. (1971 a). Eggwashing apparatus. Drosophila Information Service 47, 132–133.Google Scholar
Sparrow, J. C. (1971 b). Developmental genetics of melanotic tumour mutants in Drosophila melanogaster. D.Phil Thesis, University of Sussex.Google Scholar
Spiro, R. G. (1970). Glycoproteins. Annual Review of Biochemistry 39, 599–638.CrossRefGoogle ScholarPubMed
Thomas, K. K. & Gilbert, L. I. (1967). In vitro studies on the release and transport of phos-pholipids. Journal of Insect Physiology 13, 963.CrossRefGoogle Scholar
Willis, N. & Hodgson, E. (1970). Absence of transmethylation reactions involving choline betaine and methionine in Insecta. International Journal of Biochemistry 1, 659–662.CrossRefGoogle Scholar