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Penetrance of a rare genetic defect

Published online by Cambridge University Press:  14 April 2009

K. Sittmann
K. Sittmann
Affiliation:
Department of Genetics, McGill University, Montreal, Canada
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Contrary to the conclusion of earlier workers, penetrance of a very rare genetic defect, congenital tremor in White Leghorn chicks, was found to be complete. By appropriate correction of the original data for small family size it is shown that the defect is determined not by one but two pairs of autosomal recessive genes. In the terminology of human genetics, ascertainment of affected individuals corresponded to conditions of ‘truncate’ selection in the case of maternal sibships and more nearly to ‘single’ selection in the case of paternal sibships.

Type
Research Article
Information
Genetics Research , Volume 10 , Issue 3 , December 1967 , pp. 229 - 233
Copyright
Copyright © Cambridge University Press 1967

References

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