Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-28T04:32:00.686Z Has data issue: false hasContentIssue false
  • English
  • Français

Parental age and recombination frequency in the house mouse

Published online by Cambridge University Press:  14 April 2009

Margaret E. Wallace ,
Felicity J. MacSwiney  and
R. G. Edwards
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
Felicity J. MacSwiney
Affiliation:
Department of Genetics, University of Cambridge
R. G. Edwards
Affiliation:
Department of Physiology, University of Cambridge
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The relationship between parental age and recombination frequency in the offspring of mice has been studied using backcrosses to heterozygous males or females. The mice were allowed to breed until they became infertile. Data for several chromosomes were analysed, mostly from a stock carrying five markers covering approximately three-quarters of the length of chromosome 2.

Analyses of two-point recombination ratios or of multi-point interference ratios revealed no consistent age-related heterogeneity in offspring of male or female heterozygotes. A significant age-related heterogeneity was detected in the offspring of female heterozygotes but not of males, when the number of offspring with no detectable recombination was compared to those with one or more. This difference between the sexes could be related to earlier cytological observations on chiasma frequency in oocytes and spermatocytes. The significance of these findings for the analysis of follicular growth in mammals and in the origin of human trisomic conditions is discussed.

Type
Research Article
Information
Genetics Research , Volume 28 , Issue 3 , December 1976 , pp. 241 - 251
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Bodmer, W. F. (1961). Effect of maternal age in the incidence of congenital abnormalities in mouse and man. Nature 190, 1134–1135.CrossRefGoogle Scholar
Boué, J., Boué, A. & Lazar, P. (1975). The epidemiology of human spontaneous abortions with chromosomal anomalies. In: Aging Gametes, Their Biology & Pathology. (ed. Blandau, R. J.), pp. 330–348. Basel: S. Karger.Google Scholar
Cattanach, B. M. & Moseley, H. J. (1973). Assignment of linkage group VII to chromosome 11. Mouse News Letter 48, 31.Google Scholar
Cattanach, B. M. & Moseley, H. J. (1974 a). (T; 16) 17H complementation test. Mouse News Letter 50, 39.Google Scholar
Cattanach, B. M. & Moseley, H. J. (1974 b). Crossover suppression in heterozygotes for tobacco mouse metacentric chromosomes. Mouse News Letter 50, 41.Google Scholar
Cattanach, B. M. & Moseley, H. J. (1974 c). T(16; 17) 7Bnr. Mouse News Letter 50, 42.Google Scholar
Fisher, R. A. (1949). A preliminary linkage test with agouti and undulated mice. Heredity 3, 229–241.CrossRefGoogle Scholar
Green, M. C. (1975). Linkage map of the Mouse. Mouse News Letter 53, 10.Google Scholar
Henderson, S. A. (1970). The time and place of meiotic crossing-over. Annual Review of Genetics 4, 295–324.CrossRefGoogle ScholarPubMed
Henderson, S. A. & Edwards, R. G. (1968). Chiasma frequency and maternal age in mammals. Nature 218, 22–28.CrossRefGoogle ScholarPubMed
Luthardt, F. W. & Donahue, R. P. (1973). Pronuclear DNA synthesis in mouse eggs. Experimental Cell Research 82, 143–151.CrossRefGoogle ScholarPubMed
Lyon, M. F., Buther, J. M. & Kemp, R. (1968). The positions of the centromeres in linkage groups II and IX of the mouse. Genetical Research 11, 193–199.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Hawkus, S. (1970). Position of the centromere in linkage group XI. Mouse News Letter 42, 27.Google Scholar
Reid, D. H. & Parsons, P. A. (1963). Sex of parent and variation of recombination with age in the mouse. Heredity 18, 107–108.CrossRefGoogle ScholarPubMed
Robinson, R. (1972). Gene Mapping in Laboratory Animals. Part B. London; Plenum Press.Google Scholar
Searle, A. G. & Beechey, C. V. (1971). Position of centromere in linkage groups I and XX. Mouse News Letter 45, 25.Google Scholar
Searle, A. G., Ford, C. E. & Beechey, C. V. (1971). Meiotic disjunction in mouse translocations and the determination of centromere position. Genetical Research 18, 215–235.CrossRefGoogle ScholarPubMed
Wallace, M. E. (1957). A balanced three-point experiment for linkage group V of the house mouse. Heredity 11, 223–258.CrossRefGoogle Scholar
Wallace, M. E. (1958). Experimental evidence for a new genetic phenomenon. Philosophical Transactions of the Royal Society Series B 241, 211–254.Google Scholar
Wallace, M. E. (1971). An unprecedented number of mutants in a colony of wild mice. Environmental Pollution 1, 175–184.Google Scholar
Wallace, M. E. & MacSwiney, F. J. (1976). A major gene controlling warfarin resistance in the house mouse. Journal of Hygiene, Cambridge 76, 173–181.CrossRefGoogle Scholar