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Nutritional regulation of antennal/leg homoeotic mutants in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Trevor Jowett  and
James H. Sang
Trevor Jowett
Affiliation:
Department of Biological Sciences, University of Sussex, Brighton, Sussex, England
James H. Sang
Affiliation:
Department of Biological Sciences, University of Sussex, Brighton, Sussex, England
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The expression of the antennal homoeotic mutant, Nasobemia, is shown to be strongly dependent on nutrition. Dietary deficiencies in any of the following: thiamine, calcium pantothenate, nicotinic acid or RNA, cause a curing of the homoeotic defect. It is demonstrated that the effects of thiamine and pantothenate are through limiting acetyl-CoA synthesis and that fatty acids are required for high penetrance of the Ns gene. Similar nutritional effects are described for other Antennapedia and aristapedia alleles. The period of sensitivity to nutritional changes is defined for Ns and compared with the period of temperature sensitivity. These results suggest the hypothesis that the homoeotic mutations Antennapedia and aristapedia share some common metabolic requirements which involve synthesis of acetyl-CoA.

Type
Research Article
Information
Genetics Research , Volume 34 , Issue 2 , October 1979 , pp. 143 - 161
Copyright
Copyright © Cambridge University Press 1979

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