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Nucleotide sequence analysis of class II genes borne by mouse t chromosomes

Published online by Cambridge University Press:  14 April 2009

M. Golubić ,
O. Budimir ,
R. Schoepfer ,
M. Kasahara ,
W. E. Mayer ,
F. Figueroa  and
J. Klein
M. Golubić
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
O. Budimir
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
R. Schoepfer
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
M. Kasahara
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
W. E. Mayer
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
F. Figueroa
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
J. Klein*
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
*
†Corresponding author.
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Five class II H-2 genes borne by t chromosomes were partially sequenced: borne by the tTuw10 chromosome of EDY589 (H-2w2); and borne by the tTuw8 chromosome of CR0437 (H-2w57), as well as and borne by the tTuw7 chromosome of CR0435 (H-2w37). These genes are representatives of the three major groups of alleles found associated with t chromosomes. The sequenced part consisted of almost the entire exon 2 and the entire exon 3 coding for the first and the second domain of the β polypeptide chains, respectively. The sequence was compared with the published sequences of Aβ and Eβ alleles borne, by non-t chromosomes. The comparison revealed that the t-associated alleles are no more similar to one another than they are to the corresponding genes present on non-t chromosomes in laboratory mice. This divergence in the nucleotide sequence among the class II genes is interpreted as evidence that the t complex is very old.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 2 , October 1987 , pp. 137 - 146
Copyright
Copyright © Cambridge University Press 1987

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