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A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon  and
P. H. Glenister
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, U.K.
P. H. Glenister
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, U.K.
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Summary

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A mutation to an apparently new allele at the W-locus of the mouse arose spontaneously in a cross between two inbred strains. Heterozygotes have a broad white sash, leading to the name and symbol sash, Wsh. Homozygotes are black-eyed whites which are viable, fertile and not anaemic, although the gene does cause mild haematopoietic defects. The original mutant animal also carried a spontaneous recessive lethal mutation on chromosome 5, mapping at 2 cM distal to the W-locus.

Type
Research Article
Information
Genetics Research , Volume 39 , Issue 3 , June 1982 , pp. 315 - 322
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Evans, E. P. & Phillips, R. J. S. (1975). Inversion heterozygosity and the origin of XO daughters of Bpa/ + female mice. Nature 256, 40–41.CrossRefGoogle ScholarPubMed
Geissler, E. N., McFarland, E. C. & Russell, E. S. (1981). Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: A description of ten new W alleles. Genetics 97, 337–361.CrossRefGoogle ScholarPubMed
Guenet, J.-L., Marchal, G., Milon, G., Tambourin, P. & Wendlino, F. (1979). Fertile dominant spotting (Wf): A new allele at the W locus. Journal of Heredity 70, 9–12.CrossRefGoogle Scholar
Haldane, J. B. S. (1936). The amount of heterozygosis to be expected in an approximately pure line. Journal of Genetics 32, 375–391.CrossRefGoogle Scholar
Loutit, J. F., Corp, M. J. & Adams, P. J. V. (1982). Radiosensitivity of mice with mutation at loci W, Ph. International Journal of Radiation Biology (in press).Google ScholarPubMed
Loutit, J. F., Peters, J. & Stevens, J. (1981). Spleen colony forming cell as common precursor for tissue mast cells and granulocytes. Nature 294, 290.CrossRefGoogle ScholarPubMed
McLaren, A. (1976). Genetics of the early mouse embryo. Annual Review of Genetics 10, 361–388.CrossRefGoogle ScholarPubMed
Russell, E. S. (1979). Hereditary anaemias of the mouse: a review for geneticists. Advances in Genetics 20, 357–459.CrossRefGoogle Scholar
Schlager, G. & Dickie, M. M. (1971). Natural mutation rates in the house mouse: estimates for five specific loci and dominant mutations. Mutation Research 11, 89–96.CrossRefGoogle ScholarPubMed
Sherman, M. I. & Wudl, L. R. (1977). T-complex mutations and their effects. In Concepts in Mammalian Embryogenesis (ed. Sherman, M. I.), pp. 136–234. Cambridge, Mass.: MIT Press.Google Scholar