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The Neurospora am gene and NADP-specific glutamate dehydrogenase: mutational sequence changes and functional effects – more mutants and a summary

Published online by Cambridge University Press:  01 August 2000

J. R. S. FINCHAM ,
J. A. KINSEY ,
A. M. FUENTES ,
N. J. CUMMINGS  and
I. F. CONNERTON
J. R. S. FINCHAM
Affiliation:
Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JN, UK
J. A. KINSEY
Affiliation:
Department of Microbiology, University of Kansas Medical School, Kansas City, Kansas 66103, USA
A. M. FUENTES
Affiliation:
School of Biological Sciences, Division of Food Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
N. J. CUMMINGS
Affiliation:
School of Biological Sciences, Division of Food Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
I. F. CONNERTON
Affiliation:
School of Biological Sciences, Division of Food Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
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Abstract

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A further series of mutant am alleles, encoding potentially active NADP-specific glutamate dehydrogenase (GDH) and capable of complementation in heterocaryons, have been characterized with respect to both GDH properties and DNA sequence changes. Several mutants previously studied, and some of their same-site or second-site revertants, have also been sequenced for the first time. We present a summary of what is known of the properties of all am mutants that have been defined at the sequence level.

Type
Research Article
Information
Genetics Research , Volume 76 , Issue 1 , August 2000 , pp. 1 - 10
Copyright
© 2000 Cambridge University Press