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Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DB/2 mice

Published online by Cambridge University Press:  22 May 2007

Christina Neuschl
Affiliation:
Humboldt University of Berlin, Institute of Livestock Sciences, 10115 Berlin, Germany
Gudrun A. Brockmann
Affiliation:
Humboldt University of Berlin, Institute of Livestock Sciences, 10115 Berlin, Germany
Sara A. Knott
Affiliation:
University of Edinburgh, Institute of Evolutionary Biology, Edinburgh EH9 3JT, UK
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Multiple-trait analyses have been shown to improve the detection of quantitative trait loci (QTLs) with multiple effects. Here we applied a multiple-trait approach on obesity- and growth-related traits that were surveyed in 275 F2 mice generated from an intercross between the high body weight selected line NMRI8 and DBA/2 as lean control. The parental lines differed 2·5-fold in body weight at the age of 6 weeks. Within the F2 population, the correlations between body weight and weights of abdominal fat weight, muscle, liver and kidney at the age of 6 weeks were about 0·8. A least squares multiple-trait QTL analysis was performed on these data to understand more precisely the cause of the genetic correlation between body weight, body composition traits and weights of inner organs. Regions on Chr 1, 2, 7 and 14 for body weights at different early ages and regions on Chr 1, 2, 4, 7, 14, 17 and 19 for organ weights at 6 weeks were found to have significant multiple effects at the genome-wide level.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2007
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