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The mouse t complex distorter-3 (Tcd-3) locus and transmission ratio distortion

Published online by Cambridge University Press:  14 April 2009

Lee M. Silver  and
Christine Buck
Lee M. Silver*
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA
Christine Buck
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA
*
* Corresponding author.
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Summary

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A novel central partial t haplotype was generated by screening for a recombination event between overlapping distal and proximal partial haplotypes. This haplotype contains just two elements Tcrt and Tcd-3t —involved in the t-specific transmission ratio distortion phenotype. Breeding analysis of males that carry this chromosome provides evidence that Tcd-3 is, indeed, a distorter locus and not a second responder. Furthermore, the data indicate that a single well-defined distorter locus is insufficient to overcome completely the self-destructive, low transmission ratio distortion phenotype expressed by the t allele at the t complex responder locus, although a small, but highly significant, effect was observed.

Type
Research Article
Information
Genetics Research , Volume 62 , Issue 2 , October 1993 , pp. 133 - 137
Copyright
Copyright © Cambridge University Press 1993

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