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Mitochondrial instability in a strain of Saccharomyces cerevisiae

Published online by Cambridge University Press:  14 April 2009

I. H. Evans  and
D. Wilkie
I. H. Evans
Affiliation:
Department of Botany and Microbiology, University College London, London WC1E 6BT
D. Wilkie
Affiliation:
Department of Botany and Microbiology, University College London, London WC1E 6BT
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Summary

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A haploid strain of Saccharomyces cerevisiae has been described which, on glucose medium, segregates vegetatively a high frequency of mutants with different degrees of respiratory impairment. The range of mutants seemingly encompasses both non-revertible ρ- petites and revertible point mutations resembling leaky mit- mutations. The segregants have aberrant cytochrome contents and reduced growth capabilities on fermentable sugars other than glucose; these defects apparently correlate with the degree of respiratory impairment. Genetic analysis of this mutator phenomenon has implicated a nuclear gene which appears to show specificity of interaction with the mitochondrial genome as well as a requirement for glucose repression. The mutator effect seems to extend also to the loci in mitochondrial DNA for resistance to the antibiotics erythromycin and oligomycin.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 2 , October 1978 , pp. 171 - 182
Copyright
Copyright © Cambridge University Press 1978

References

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