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Meiotic drive in female mice heterozygous for the HSR inserts on chromosome 1

Published online by Cambridge University Press:  14 April 2009

Sergei I. Agulnik ,
Alexander I. Agulnik  and
Anatoly O. Ruvinsky
Sergei I. Agulnik
Affiliation:
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk-90
Alexander I. Agulnik
Affiliation:
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk-90
Anatoly O. Ruvinsky*
Affiliation:
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk-90
*
* Corresponding author.
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Summary

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Chromosome 1 with one or two long insertions has been previously found in natural mouse populations. The inheritance of chromosome 1 with two insertions from the Yakutsk population is analysed in this paper. It was demonstrated that heterozygous females transmit this chromosome to 80–85% of offspring. The observations made at M II, in conjunction with the recombination data, allowed us to conclude that preferential passage of the chromosome 1 with insertions to the oocyte and egg, rather than to the first and second polar bodies at meiosis, is the causative factor of the distorted segregation. A meiotic drive of such potency has not been previously reported for female mammals. The possible mechanism of the drive is discussed.

Type
Research Article
Information
Genetics Research , Volume 55 , Issue 2 , April 1990 , pp. 97 - 100
Copyright
Copyright © Cambridge University Press 1990

References

Agulnik, S. I., Agulnik, A. I. & Ruvinsky, A. O. (1988 a). Meiotic drive in female mice heterozygous for Chr 1 with two insertions. Mouse News Letter 81, 78–79.Google Scholar
Agulnik, S. I., Agulnik, A. I. & Ruvinsky, A. O. (1989 a). Localization of insertions Is(HSR;1C5)1Icg and Is(HSR;1D)2Icg on a genetic map. Mouse News Letter 84, 51.Google Scholar
Agulnik, S. I., Borodin, P. M., Gorlov, I. P., Ladygina, T. Yu & Pak, S. D. (1989 b). Causes of a double insertion of homogeneously staining regions in the house mouse (Mus musculus musculus). Genetika (in Russian) (in the press).Google Scholar
Agulnik, S. I., Gorlov, I. P. & Agulnik, A. I. (1988 b). New variant of chromosome 1 in the house mouse Mus musculus. Tsitologia 30, 770–773 (in Russian).Google Scholar
Boldyreff, B., Winking, H., Weith, A. & Traut, W. (1988). Evidence for in situ amplification of a germ line homogeneously staining region in the mouse. Cytogenetics and Cell Genetics 47, 84–85.CrossRefGoogle ScholarPubMed
Borodin, P. M., Ladygina, T. Yu. & Gorlov, I. P. (1989). The effect of heterozygosity for two insertions of homogeneously stained regions in the chromosome 1 of the house mouse on synapsis in meiotic prophase. Genetika 25, 214–219 (in Russian).Google Scholar
Dyban, A. P. & Baranov, V. S. (1978). Cytogenetics of Mammalian Development, 216 pp. Moscow, Nauka (in Russian).Google Scholar
Gilova, E. A. & Chebotar, N. A. (1979). Preovulatory stages of gametogenesis, sex chromosome and B chromosome behaviour at the female meiosis of Dicrostonyx torquatus Pall. Tsitologia 21, 798–801 (in Russian).Google Scholar
Ladygina, T. Yu., Gorlov, I. P. & Borodin, P. M. (1989). Effect of the double insertion of homogeneously stained regions in the chromosome 1 of the house mouse on recombination frequency. Genetika 25, 220–225 (in Russian).Google ScholarPubMed
Luthardt, F. W. (1976). Cytogenetic analysis and early preimplantation embryos from XO mice. Developmental Biology 54, 73–81.CrossRefGoogle ScholarPubMed
Rhoades, M. M. (1942). Preferential segregation in maize. Genetics 27, 395–407.CrossRefGoogle ScholarPubMed
Rhoades, M. M. (1952). Preferential Segregation in Maize. Heterosis, pp. 66–80. Ames, Iowa, Iowa State College Press.Google Scholar
Rhoades, M. M. & Dempsey, E. (1966). the effect of abnormal chromosome 10 on preferential segregation and crossing-over in maize. Genetics 53, 938–1020.CrossRefGoogle ScholarPubMed
Ruvinsky, A. O., Agulnik, S. I., Agulnik, A. I. & Belyaev, D. K. (1987). The influence of mutations on chromosome 17 upon the segregation of homologues in female mice heterozygous for Robertsonian translocations. Genetical Research 50, 235–237.CrossRefGoogle ScholarPubMed
Ruvinsky, A. O., Agulnik, S. I., Agulnik, A. I. & Belyaev, D. K. (1988). Structural changes of the homologues as a possible cause of abnormal disjunction in female mice heterozygous for Robertsonian translocations. Génétique, Selection, Évolution 20, 299–306.CrossRefGoogle ScholarPubMed
Thomson, R. L. (1984). B chromosomes in Rattus fuscipes. II: The transmission of B chromosomes to offspring and population studies support for the ‘parasitic’ model. Heredity 52, 363–372.CrossRefGoogle Scholar
Traut, W., Winking, H. & Adolph, S. (1984). An extra segment in chromosome 1 of wild Mus musculus: a C- band positive homogeneously staining region. Cytogenetics and Cell Genetics 38, 290–297.CrossRefGoogle Scholar
Weith, A., Winking, H., Brackmann, B., Boldyreff, B. & Traut, W. (1987). Microclones from a mouse germ line HSR detect amplification and complex rearrangement of DNA sequences. EMBO Journal 6, 1295–1300.CrossRefGoogle ScholarPubMed
Yakimenko, L. V. & Korobitsina, K. V. (1988). A rare variant of the chromosome 1 in house mouse: occurrence of two extra heterochromatin segments. Genetika 24, 376–378 (in Russian).Google Scholar