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Male meiotic behaviour and male and female litter size in mice with the T(2; 8)26H and T(1; 13)70H reciprocal translocations

Published online by Cambridge University Press:  14 April 2009

P. de Boer
P. de Boer
Affiliation:
Department of Genetics, Agricultural University, Wageningen, The Netherlands
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Two reciprocal mouse translocations T(2; 8)26H and T(1; 13)70H, heterozygous in a Swiss random-bred background, show differences in the spectrum of multivalent configurations and in the segregational behaviour of these multivalent configurations. T26H/+ males mostly contained rings of four (R IV, 53·15%) and T70H/+ males chains of four, missing a chiasma in the shortest interstitial segment (C IV 11, 61·55%). The adjacent II frequency, estimated from metaphase II observations, was 8·47% in T26H/+ and 25·22% in T70H/+. Univalents of the shorter translocation chromosome of T70H are able to divide equationally at first anaphase. The hypothesis is advanced that time differences in chiasma terminalization during metaphase I-anaphase are important for explaining the difference in segregation observed between the two translocations. Translocation-caused non-disjunction is probably low in T26H/+ and 4–5% in T70H/+. Univalents involving T70H/+ are usually capable of co-orientation with the other chromosomes of the translocation complex. The summed percentages of adjacent II disjunction and non-disjunction caused by the translocations were estimated from the relative fertility scores of T/+ males and females versus +/+ males and females as 9·8% and 29·0% for T26H/+ and T70H/+ males, respectively, and 9·4% and 27·8% for T26H/+ females and T70H/+ females. For both translocations, the agreement between the various estimates is good. Chiasma frequencies are much higher in telomeric segments than in proximal segments containing centric heterochromatin.

Type
Research Article
Information
Genetics Research , Volume 27 , Issue 3 , June 1976 , pp. 369 - 387
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Baranov, V. S. & Dyban, A. P. (1968). Analysis of spermatogenic and embryogenic abnormalities in mice, heterozygous for the chromosome translocation T6. Genetika (U.S.S.R.) 4, 70–83.Google Scholar
de Boer, P. (1973). Fertile teriary trisomy in the mouse (Mus musculus). Cytogenetics and Cell Genetics 12, 435–442.CrossRefGoogle Scholar
de Boer, P. & Groen, A. (1974). Fertility and meiotic behavior of male T70H tertiary trisomics of the mouse (Mus musculus). A case of preferential telomeric meiotic pairing in a mammal Cyfogeneftca and Cell Genetics 13, 489–510.CrossRefGoogle ScholarPubMed
de Boer, P. & van Gijsen, M. (1974). The location of the position of the breakpoints involved in the T26H and T70H mouse translocations with the aid of Giemsa-banding. Canadian Journal of Genetics and Cytology 16, 783–788.CrossRefGoogle ScholarPubMed
Bryan, J. H. D. (1970). An eosin-fast green-naphthol yellow mixture for differential staining of the cytologic components in mammalian spermatozoa. Stain Technology 45, 231–236.CrossRefGoogle ScholarPubMed
Burnham, C. R. (1950). Chromosome segregation in translocations involving chromosome 6 in maize. Genetics 35, 446–481.CrossRefGoogle ScholarPubMed
Carter, T. C., Lyon, M. F. & Phillips, R. J. S. (1955). Gene-tagged chromosome translocationsin eleven stocks of mice. Journal of Genetic 53, 154–166.CrossRefGoogle Scholar
Cook, P. J. L., Robson, E. B., Buckion, K. E., Jacobs, P. A. & Polani, P. E. (1974). Segregation of genetic markers in families with chromosome polymorphisms and structural rearrangements involving chromosome 1. Annals of Human Genetics 37, 261–274.CrossRefGoogle ScholarPubMed
Eicher, E. M. (1973). Translocation trisomic mice: production by female but not male translocation carriers. Scinece 180, 81.CrossRefGoogle Scholar
Eicher, E. M. & Green, M. C. (1972). The T6 translocation in the mouse: its use in trisomy mapping, centromere localization, and cytological indemnification of linkage group II. Genetics 71, 621–632.CrossRefGoogle Scholar
Evans, E. P., Breckon, C. & Ford, C. E. (1964). An air-drying method for meiotic preparations from mammalian testes. Cytogenetics 3, 289–294.CrossRefGoogle ScholarPubMed
Ford, C. E., Carter, T. C. & Hamerton, J. L. The cytogenetics of reciprocal translocations in the mouse: a survey of twelve stocks. (Unpublished.)Google Scholar
Forejt, J. (1972). Chiasmata and crossing-over in the male mouse (Mus musculus). Suppression of recombination and chiasma frequencies in the ninth linkage group. Folia Biologia 18, 161–170.Google ScholarPubMed
Forejt, J. (1973). Pseudochiasmata in male meiosis? Mouse News Letter 49, 46.Google Scholar
Fredga, K. (1964). A simple technique for demonstration of the chromosomes and mitotic stages in a mammal. Hereditas 51, 268–273.CrossRefGoogle Scholar
Lewis, K. R. & John, B. (1963). Spontaneous interchange in Chorthippus brunneus. Chromosoma 14, 618–637.CrossRefGoogle Scholar
Lyon, M. F., Glenister, P. H. & Hawker, S. G. (1972). Do the H-2 and T-loci of the mouse have a function in the haploid phase of sperm? Nature 240, 152–153.CrossRefGoogle ScholarPubMed
Ohno, S., Kaplan, W. D. & Kinosita, R. (1959). Do XY- and O-sperm occur in Mus musculus? Experimental Cell Research 18, 382–384.CrossRefGoogle ScholarPubMed
Searle, A. G. (1974). Nature and consequences of induced chromosome damage in mammals. Genetics 78, 173–186.CrossRefGoogle ScholarPubMed
Searle, A. G. & Beechey, C. V. (1974). Sperm-count, egg-fertilization and dominant lethality after X-irradiation of mice. Mutation Research 22, 63–72.CrossRefGoogle ScholarPubMed
Searle, A. G., Ford, C. E. & Beechzy, C. V. (1971). Meiotic disjunction in mouse translocations and the determination of centromere position. Genetical Research 18, 215–235.CrossRefGoogle ScholarPubMed
Snell, G. D. (1946). An analysis of translocations in the mouse. Genetics 31, 157–180.CrossRefGoogle ScholarPubMed
Sumner, A. T. (1972). A simple technique for demonstrating centromeric heterochromatin. Experimental Cell Research 75, 304–306.CrossRefGoogle Scholar