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Male meiotic behaviour and male and female litter size in mice with the T(2; 8)26H and T(1; 13)70H reciprocal translocations

Published online by Cambridge University Press:  14 April 2009

P. de Boer
P. de Boer
Affiliation:
Department of Genetics, Agricultural University, Wageningen, The Netherlands
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Two reciprocal mouse translocations T(2; 8)26H and T(1; 13)70H, heterozygous in a Swiss random-bred background, show differences in the spectrum of multivalent configurations and in the segregational behaviour of these multivalent configurations. T26H/+ males mostly contained rings of four (R IV, 53·15%) and T70H/+ males chains of four, missing a chiasma in the shortest interstitial segment (C IV 11, 61·55%). The adjacent II frequency, estimated from metaphase II observations, was 8·47% in T26H/+ and 25·22% in T70H/+. Univalents of the shorter translocation chromosome of T70H are able to divide equationally at first anaphase. The hypothesis is advanced that time differences in chiasma terminalization during metaphase I-anaphase are important for explaining the difference in segregation observed between the two translocations. Translocation-caused non-disjunction is probably low in T26H/+ and 4–5% in T70H/+. Univalents involving T70H/+ are usually capable of co-orientation with the other chromosomes of the translocation complex. The summed percentages of adjacent II disjunction and non-disjunction caused by the translocations were estimated from the relative fertility scores of T/+ males and females versus +/+ males and females as 9·8% and 29·0% for T26H/+ and T70H/+ males, respectively, and 9·4% and 27·8% for T26H/+ females and T70H/+ females. For both translocations, the agreement between the various estimates is good. Chiasma frequencies are much higher in telomeric segments than in proximal segments containing centric heterochromatin.

Type
Research Article
Information
Genetics Research , Volume 27 , Issue 3 , June 1976 , pp. 369 - 387
Copyright
Copyright © Cambridge University Press 1976

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