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Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster: II. Lethals and visible mutants with large effects

Published online by Cambridge University Press:  14 April 2009

B. H. Yoo
B. H. Yoo
Affiliation:
Department of Animal Husbandry, University of Sydney, Sydney, N.S.W., Australia
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Lethal frequencies on the second and third chromosomes were estimated three times in six replicate lines of Drosophila melanogaster selected for increased abdominal bristle number, at G 14–16, G 37–44 and G 79. Ten lethals were detected at a frequency of about 5% or higher at G 14–16, of which only one recurred in subsequent tests. Another ten lethals which had not been detected previously were found at G 37–44, and the 5 most frequent ones recurred at G 79. In the last test, 15 presumably new lethals were detected, of which at least 4 appeared well established. In addition, six reversions (from sc to sc+), a new mutant at the scute locus and sca were discovered. The effects on the selected character of some lethals and visible mutants were large and variable, but not always sufficient to explain the observed frequencies. The major lethals detected at G 37–44 and G 79 for the first time were most probably ‘mutations’ (in the broad sense) which occurred during selection. The likely origins of such ‘mutations’ were discussed, with a suggestion that the known mutation rate for recessive lethals would not be incompatible with the observed frequency of occurrence of the ‘mutations’.

Type
Research Article
Information
Genetics Research , Volume 35 , Issue 1 , February 1980 , pp. 19 - 31
Copyright
Copyright © Cambridge University Press 1980

References

REFERENCES

Clayton, G. A. & Robertson, A. (1957). An experimental check on quantitative genetical theory. II. The long-term effects of selection. Journal of Genetics 55, 152–170.CrossRefGoogle Scholar
Clayton, G. A. & Robertson, A. (1964). The effects of X-rays on quantitative characters. Genetical Research 5, 410–422.CrossRefGoogle Scholar
Comstock, R. E. (1973). Growth in mice. Genetics 74 (06 Suppl.), 51–52.Google Scholar
Crow, J. F. & Temin, R. G. (1964). Evidence for the partial dominance of recessive lethal genes in natural populations of Drosophila. American Naturalist 98, 21–33.CrossRefGoogle Scholar
Dobzhansky, Th. & Spassky, B. (1960). Release of genetic variability through recombination. V. Breakup of synthetic lethals by crossing over in Drosophila pseudoobscura. Zoologische Jahrbücher Systematik, Ökologie und Geographie der Tiere 88, 57–66.Google Scholar
Frankham, R., Briscoe, D. A. & Nurthen, R. K. (1978). Unequal crossing over at the rRNA locus as a source of quantitative genetic variation. Nature 272, 80–81.CrossRefGoogle ScholarPubMed
Frankham, R., Jones, L. P. & Barker, J. S. F. (1968). The effects of population size and selection intensity in selection for a quantitative character in Drosophila. III. Analyses of the lines. Genetical Research 12, 267–283.CrossRefGoogle Scholar
Hollingdale, B. (1971). Analyses of some genes from abdominal bristle number selection lines in Drosophila melanogaster. Theoretical and Applied Genetics 41, 292–301.CrossRefGoogle Scholar
Hollingdale, B. & Barker, J. S. F. (1971 a). Selection for increased abdominal bristle number in Drosophila melanogaster with concurrent irradiation. I. Populations derived from an inbred line. Theoretical and Applied Genetics 41, 208–215.CrossRefGoogle ScholarPubMed
Hollingdale, B. & Barker, J. S. F. (1971 b). Seletion for increased abdominal bristle number in Drosophila melanogaster with concurrent irradiation. II. Populations derived from an outbred cage population. Theoretical and Applied Genetics 41, 263–274.CrossRefGoogle Scholar
Jones, L. P., Frankkam, R. & Barker, J. S. F. (1968). The effects of population size and selection intensity in selection for a quantitative character in Drosophila. II. Long-term response to selection. Genetical Research 12, 249–266.CrossRefGoogle Scholar
Kojima, K. (1969). Genetic variability and selection response in quantitative traits. Japanese Journal of Genetics 44, (Suppl. 1), 294–298.Google Scholar
Lande, R. (1976). The maintenance of genetic variability by mutation in a poly genie character with linked loci. Genetical Research 26, 221–235.CrossRefGoogle Scholar
Latter, B. D. H. & Robertson, A. (1962). The effects of inbreeding and artificial selection on reproductive fitness. Genetical Research 3, 110–138.CrossRefGoogle Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster. Carnegie Institute of Washington Publications, 627.Google Scholar
Madalena, F. E. & Robertson, A. (1975). Population structure in artificial selection: studies with Drosophila melanogaster. Genetical Research 24, 113–126.CrossRefGoogle Scholar
Rathie, K. A. (1969). Faster scoring of a quantitative trait of Drosophila melanogaster. Drosophila Information Service 44, 104.Google Scholar
Rathie, K. A. (1976). Artificial selection with differing population structures. Ph.D. thesis, University of Sydney.Google Scholar
Reeve, E. C. R. & Robertson, F. W. (1953). Studies in quantitative inheritance. II. Analysis of a strain of Drosophila melanogaster selected for long wings. Journal of Genetics 51, 276–316.CrossRefGoogle Scholar
Robertson, A. (1966). Artificial selection in plants and animals. Proceedings of the Royal Society B 164, 341–349.Google ScholarPubMed
Robertson, A. (1978). The time of detection of recessive visible genes in small populations. Genetical Research 31, 255–264.CrossRefGoogle Scholar
Scossiroli, R. E. & Scossiroli, S. (1959). On the relative role of mutation and recombination in responses to selection for polygenic traits in irradiated populations of D. melanogaster. International Journal of Radiation Biology 1, 61–69.Google Scholar
Thoday, J. M., Gibson, J. B. & Spickett, S. C. (1964). Regular responses to selection. 2. Recombination and accelerated response. Genetical Research 5, 1–19.CrossRefGoogle Scholar
Waddington, C. H. (1957). The Strategy of the Genes. London: Allen and Unwin.Google Scholar
Wallace, B., King, J. C., Madden, C. V., Kaufmann, B. & McGunnigle, E. C. (1953). An analysis of variability arising through recombination. Genetics 38, 272–307.CrossRefGoogle ScholarPubMed
Watt, W. B. (1972). Intragenic recombination as a source of population genetic variability. American Naturalist 106, 737–753.CrossRefGoogle Scholar
Yoo, B. H. (1974). Correlated responses of different scute genotypes to long-term selection for increased abdominal bristle number in Drosophila melanogaster. Australian Journal of Biological Science 27, 205–218.CrossRefGoogle ScholarPubMed
Yoo, B. H. (1979 a). Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster. I. Response to selection. Genetic Research 35, 1–17.CrossRefGoogle Scholar
Yoo, B. H. (1979 b). Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster. III. The nature of residual genetic variability. Theoretical and Applied Genetics (in press).CrossRefGoogle Scholar