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Localization of the properdin factor complement locus Pfc to band A3 on the mouse X chromosome

Published online by Cambridge University Press:  14 April 2009

E. P. Evans
Affiliation:
Sir William Dunn School of Pathology, South Parks Road, Oxford, U.K.
M. D. Burtenshaw
Affiliation:
Sir William Dunn School of Pathology, South Parks Road, Oxford, U.K.
S. H. Laval
Affiliation:
Genetics Division, MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 ORD, U.K.
D. Goundis
Affiliation:
MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford, U.K.
K. B. M. Reid
Affiliation:
MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford, U.K.
Y. Boyd*
Affiliation:
Genetics Division, MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 ORD, U.K.
*
Corresponding author.
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Summary

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The locus for properdin (properdin factor complement, Pfc), a plasma glycoprotein, has been mapped to band A3 of the mouse X chromosome by in situ hybridization to metaphase spreads containing an X;2 Robertsonian translocation. The X-linkage of the locus has also been confirmed by analysis of Mus musculus x Mus spretus interspecific crosses. The XA3 localization for Pfc places it in the chromosomal segment conserved between man and mouse which is known to contain at least six other homologous loci (Cybb, Otc, Syn-1 Maoa, Araf, Timp).

Type
Research Article
Copyright
Copyright © Cambridge University Press 1990

References

Adler, I.-D., Johannisson, R. & Winking, H. (1989). The influence of the Robertsonian translocation Rb(X.2)2AD on anaphase I non-disjunction in male laboratory mice. Genetica! Research 53, 7786.CrossRefGoogle Scholar
Adolph, S., Bartram, C. R. & Hameister, H. (1987). Mapping of the oncogenes Myc, Sis and Int-1 to the distal part of mouse chromosome 15. Cytogenetics and Cell Genetics 44, 6568.CrossRefGoogle Scholar
Amar, L. C., Dandalo, L., Hanauer, A., Ryder, Cook A., Arnaud, D., Mandel, J.-L. & Avner, P. (1988). Conservation and reorganisation of loci on the mammalian X chromosome: A molecular framework for the identification of homologous subchromosomal regions in man and mouse. Genomics 2, 220230.CrossRefGoogle Scholar
Derry, J. M. J., Lan, N. C., Shih, J. C., Barnard, E. A. & Barnard, P. J. (1989). Localisation of the monoamine oxidase A and B genes on the mouse X chromosome. Cytogenetics and Cell Genetics 51, 987988.Google Scholar
Feinberg, A. P. & Vogelstein, B. (1983). A technique for radiolabelling DNA restriction fragments to high specific activity. Analytical Biochemistry 132, 613.CrossRefGoogle ScholarPubMed
Goonewardena, P., Sjoholm, A. G., Nilsson, L-A. & Petterson, U. (1988). Linkage analysis of the properdin deficiency gene: Suggestion of a locus in the proximal part of the short arm of the X chromosome. Genomics 2, 115118.CrossRefGoogle ScholarPubMed
Goundis, D. (1988). Structure, biosynthesis and isolation of cDNA and genomic clones from properdin of the serum complement system. D. Phil, thesis, University of Oxford.Google Scholar
Goundis, D. & Reid, K. B. M. (1988). Properdin, the terminal complement components, thrombospondin and CS protein of malaria parasites contain similar sequence motifs. Nature 335, 8285.CrossRefGoogle Scholar
Goundis, D., Holt, S. M., Boyd, Y. & Reid, K. B. M. (1989). Localisation of the properdin structural locus to Xp 11.23-Xp21.1. Genomics 5, 5660.CrossRefGoogle Scholar
Laval, S. & Boyd, Y. (1990). Production of large quantities of genomic DNA from newborn mice. Mouse Genome 86, 257.Google Scholar
Levy, E. R., Powell, J. F., Buckle, V. J., Yun-Pung, P. Hsu, Breakefield, X. D. & Craig, I. W. (1989). Localization of human monoamine oxidase-A gene to Xpll.23-Xpll.4 by in situ hybridisation: implications for Norrie disease. Genomics 5, 368370.CrossRefGoogle ScholarPubMed
Mandel, J.-L., Willard, H. F., Nussbaum, R. L., Romeo, G., Puck, J. M. & Davies, K. E. (1989). Report of the committee on the genetic constitution of the X chromosome. Cytogenetics and Cell Genetics 51, 384437.CrossRefGoogle Scholar
Searle, A. G., Peters, J., Lyon, M. F., Hall, J. G., Evans, E. P., Edwards, J. H. & Buckle, V. J. (1989). Chromosome maps of man and mouse IV. Annals of human Genetics 53, 89140.CrossRefGoogle ScholarPubMed
Sjoholm, A. G., Braconier, J.-H. & Soderstrom, C. (1982). Properdin deficiency in a family with fulminant meningococcal infections. Clinical and Experimental Immunology 50, 291297.Google Scholar
Thompson, R. A. (1987). Inherited complement deficiencies. In Complement in Health and Disease (ed. Whaley, K.) p. 37. Lancaster: MTP Press.Google Scholar
Yang-Feng, T. L., DeGennaro, L. J. & Francke, U. (1986). Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proceedings of the National Academy of Sciences USA 83, 86798683.CrossRefGoogle ScholarPubMed