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Linkage relationships of markers on chromosome 17 of the house mouse

Published online by Cambridge University Press:  14 April 2009

Graig Hammerberg  and
Jan Klein
Graig Hammerberg
Affiliation:
Department of Human Genetics, The University of MichiganSchool of Medicine, Ann Arbor, Michigan 48104
Jan Klein
Affiliation:
Department of Microbiology, The University of Texas, Southwestern Medical School, Dallas, Texas 75235
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Linkage data for the following markers on chromosome 17 of the house mouse were obtained: centromere (marked by translocation R67), Brachyury (T), tufted (tf), H-2, and thin fur (thf). The markers were found to be arranged in that order in the genetic map and the combined genetic distances between individual markers were found to be as follows: Rb7…T, 4·5 cM; T…tf, 5·8 cM; tf…H-2, 5·0 cM; H-2…thf, 15·1 cM. The localization of the thf locus on the non-centromeric side of the H-2 complex provides an important marker for this arm of chromosome 17. The map distances in the centromeric portion of chromosome 17 changed drastically in the presence of various t factors. These factors strongly reduce the recombination frequency in the T…tf and tf…H-2 intervals and this crossing-over suppression is most likely responsible for the linkage disequilibrium between t and H-2 reported earlier. Recombinants involving a t chromosome but occurring to the right of the H-2 complex do not change the properties of t factors suggesting that all determinants responsible for the t phenotype are located in the chromosomal region between T and tf (H-2).

Type
Research Article
Information
Genetics Research , Volume 26 , Issue 2 , October 1975 , pp. 203 - 211
Copyright
Copyright © Cambridge University Press 1975

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