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The limits to artificial selection for body weight in the mouse: III. Selection from crosses between previously selected lines

Published online by Cambridge University Press:  14 April 2009

R. C. Roberts
R. C. Roberts
Affiliation:
A.R.C. Unit of Animal Genetics, Institute of Animal Genetics, Edinburgh, 9
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1. Four lines selected for large size were crossed to form a base population for further selection for high 6-week weight; three small lines were crossed similarly, and the crossbred population was selected for low 6-week weight.

2. In every case, a cross between two selected lines resulted in heterosis increasing body weight. This shows that all of the selected lines were differentiated with respect to genes affecting body weight.

3. Further selection for large size produced a stock whose mean weight was 25% higher than the largest of the original lines at its limit. But the response to selection for small size was slow, and after twenty-four generations of selection, the low weights of two of the original lines had not been recovered.

4. The evidence points to linkage of genes affecting body weight in the mouse. It is suggested that this is a particular feature of crosses between previously selected lines, rather than a general feature of mouse populations.

Type
Research Article
Information
Genetics Research , Volume 9 , Issue 1 , February 1967 , pp. 73 - 85
Copyright
Copyright © Cambridge University Press 1967

References

REFERENCES

Bloom, J. L. (1964). Body size and lung-tumor susceptibility in outbred mice. J. natn. Cancer Inst. 33, 509–606.Google ScholarPubMed
Bodmer, W. F. & Parsons, P. A. (1962). Linkage and recombination in evolution. Adv. Genet. 11, 2–100.Google Scholar
Falconer, D. S. (1960). Selection of mice for growth on high and low plains of nutrition. Genet. Res. 1, 91–113.CrossRefGoogle Scholar
Falconer, D. S. (1964). Maternal effects and selection response. In Genetics Today. Proc. XIth int. Congr. Genet. (The Hague) 1963, Vol. III, 763–774.Google Scholar
Falconer, D. S. & Bloom, J. L. (1962). A genetic study of induced lung-tumors in mice. Br. J. Cancer, 16, 665–685.CrossRefGoogle Scholar
Falconer, D. S. & Bloom, J. L. (1964). Changes in susceptibility to urethane-induced lung tumors produced by selective breeding in mice. Br. J. Cancer, 18, 322–332.CrossRefGoogle ScholarPubMed
Falconer, D. S. & King, J. W. B. (1953). A study of selection limits in the mouse. J. Genet. 51, 561–581.CrossRefGoogle Scholar
Fargie, B. & Holloway, B. W. (1965). Absence of clustering of functionally related genes in Pseudomonas aeruginosa. Genet. Res. 6, 284–299.CrossRefGoogle ScholarPubMed
Goodale, H. D. (1938). A study of the inheritance of body weight in the albino mouse by selection. J. Hered. 29, 101–112.CrossRefGoogle Scholar
Goodale, H. D. (1941). Progress report on possibilities in progeny-test breeding. Science, N.Y. 94, 442–443.CrossRefGoogle ScholarPubMed
Hill, W. G. & Robertson, A. (1966). The effect of linkage on limits to artificial selection. Genet. Res. 8, 269–294.CrossRefGoogle ScholarPubMed
MacArthur, J. W. (1944). Genetics of body size and related characters. I. Selecting small and large races of the laboratory mouse. Am. Nat. 78, 142–157.CrossRefGoogle Scholar
MacArthur, J. W. (1949). Selection for small and large size in the house mouse. Genetics, 34, 194–209.CrossRefGoogle ScholarPubMed
Mather, K. (1943). Polygenic inheritance and natural selection. Biol. Rev. 18, 32–64.CrossRefGoogle Scholar
Mather, K. & Harrison, B. J. (1949). The manifold effect of selection. Part I. Heredity, Lond. 3, 1–52.CrossRefGoogle Scholar
Roberts, R. C. (1966 a). The limits to artificial selection for body weight in the mouse. I. The limits attained in earlier experiments. Genet. Res. 8, 347–360.CrossRefGoogle ScholarPubMed
Roberts, R. C. (1966 b). The limits to artificial selection for body weight in the mouse. II. The genetic nature of the limits. Genet. Res. 8, 361–375.CrossRefGoogle ScholarPubMed
Robertson, A. (1960). A theory of limits in artificial selection. Proc. R. Soc. B, 153, 234–249.Google Scholar
Thoday, J. M., Gibson, J. B. & Spickett, S. G. (1964). Regular responses to selection. II. Recombination and accelerated response. Genet. Res. 5, 1–19.CrossRefGoogle Scholar