Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-26T16:51:50.620Z Has data issue: false hasContentIssue false
  • English
  • Français

A lethal mutation (cab) affecting heart function in the mouse

Published online by Cambridge University Press:  14 April 2009

Francine B. Essien
Francine B. Essien
Affiliation:
Department of Biological Sciences, Douglass College, Rutgers University, New Brunswick, New Jersey 80903
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A new autosomal recessive gene (cab, ‘cardiac abnormality’), which affects heart differentiation appeared spontaneously in our mouse colony. The affected homozygotes die approximately half a day prior to birth or at term, with the myocardium exhibiting vacuolation and large areas of mesenchyme-like cells. A significant finding in mutant foetuses is the lack of histochemically detectable glycogen.

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 1 , February 1979 , pp. 57 - 59
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Bajusz, E. (1969). Hereditary cardiomyopathy: A new disease model. American Heart Journal 77, 686–696.CrossRefGoogle ScholarPubMed
Ferrans, V., McAllister, H., & Haese, W. (1976). Infantile cardiomyopathy with histiocytoid change in cardiac muscle cells. Circulation 53, 708–719.CrossRefGoogle ScholarPubMed
Gluecksohn-Waelsch, S. (1963). Lethal genes in the analysis of differentiation. Science 142, 1269–1276.Google Scholar
Pai, A. (1965). Developmental genetics of a lethal mutation in the mouse. I. Genetic analysis and gross morphology. Developmental Biology 11, 82–92.CrossRefGoogle ScholarPubMed
Scotti, T. (1977). In Pathology (eds. Anderson, W. and Kissane, J.). St Louis: Mosby (1).Google Scholar