Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-25T16:47:57.716Z Has data issue: false hasContentIssue false

A large-scale screening of the normalized mammalian mitochondrial gene expression profiles

Published online by Cambridge University Press:  15 December 2005

SERGEY V. ANISIMOV
Affiliation:
Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Mammalian mitochondrial genomes are organized in a conserved and extremely compact manner, encoding molecules that play a vital role in oxidative phosphorylation (OXPHOS) and carry out a number of other important biological functions. A large-scale screening of the normalized mitochondrial gene expression profiles generated from publicly available mammalian serial analysis of gene expression (SAGE) datasets (over 17·7 millions of tags) was performed in this study. Acquired SAGE libraries represent an extensive range of human, mouse, rat, bovine and swine cell and tissue samples (normal and pathological) in a variety of conditions. Using a straightforward in silico algorithm, variations in total mitochondrial gene expression, as well as in the expression of individual genes encoded by mitochondrial genomes are addressed, and common patterns in the species- and tissue-specific mitochondrial gene expression profiles are discussed.

Type
Research Article
Copyright
© 2005 Cambridge University Press
Supplementary material: PDF

Anisimov Supplementary Material

Table.pdf

Download Anisimov Supplementary Material(PDF)
PDF 1.5 MB