Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-30T20:18:28.488Z Has data issue: false hasContentIssue false
  • English
  • Français

Jumping genes meet abdominal bristles: hybrid dysgenesis-induced quantitative variation in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Trudy F. C. Mackay
Trudy F. C. Mackay
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

When males from a strain of Drosophila melanogaster which have multiple copies of the P family of transposable elements integrated into their genome (Bingham, Kid well & Rubin, 1982) (‘P’ strains) are crossed to females of strains lacking those elements (‘M’ strains), the F1 progeny manifest a number of aberrant traits known collectively as hybrid dysgenesis (Kidwell, Kidwell & Sved, 1977). Progeny of the reciprocal cross (P♀ × ♂M) are normal. The dysgenic syndrome is characterized by a high degree of genomic instability caused by enhanced transposition of P elements. Since mutations at visible loci and chromosomal rearrangements are frequently observed in dysgenic hybrids, it was hypothesized that this phenomenon could be used to investigate the effects of transposition on quantitative characters; therefore, the progeny of dysgenic and non-dysgenic crosses were artificially selected for high and low abdominal bristle number. The response to selection, phenotypic variation, and realized heritability were all increased in the dysgenic lines, relative to the non-dysgenic control. It is postulated that these features are the result of P element-induced mutations of loci affecting bristle number, and that future work should lead to the identification of these loci, as well as elucidating the role of transposition in population differentiation for metric traits

Type
Short Paper
Information
Genetics Research , Volume 44 , Issue 2 , October 1984 , pp. 231 - 237
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Bingham, P. M., Kidwell, M. G. & Rubin, G. M. (1982). The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain-specific transposon family. Cell 29, 995–1004.CrossRefGoogle Scholar
Engels, W. R. (1979). Hybrid dysgenesis in Drosophila melanogaster: rules of inheritance of female sterility. Genetical Research 33, 219–236.CrossRefGoogle Scholar
Engels, W. R. (1983). The P family of transposable elements in Drosophila. Annual Review of Genetics 17, 315–344.CrossRefGoogle Scholar
Falconer, D. S. (1981). Introduction to Quantitative Genetics. London: Longman.Google Scholar
Hill, W. G. (1972). Estimation of realized heritabilities from selection experiments. I. Divergent selection. Biometrics 28, 747–765.CrossRefGoogle Scholar
Kidwell, M. G., Kidwell, J. F. & Sved, J. A. (1977). Hybrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility, and male recombination. Genetics 86, 813–833.CrossRefGoogle ScholarPubMed
Lewontin, R. C. (1974). The Genetic Basis of Evolutionary Change. New York: Columbia University Press.Google Scholar
O'Hare, K. & Rubin, G. M. (1983). Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell 34, 25–35.CrossRefGoogle ScholarPubMed
Rubin, G. M., Kidwell, M. G. & Bingham, P. M. (1982). The molecular basis of P-M hybrid dysgenesis: the nature of induced mutations. Cell 29, 987–994.CrossRefGoogle ScholarPubMed
Williamson, P. G. (1981). Palaeontological documentation of speciation in Cenozoic molluscs from Turkana Basin. Nature 293, 437–443.CrossRefGoogle Scholar