Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-08T10:27:59.697Z Has data issue: false hasContentIssue false
  • English
  • Français

Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse

Published online by Cambridge University Press:  14 April 2009

Margaret E. Wallace ,
P. J. Knights  and
Janice R. Anderson
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
P. J. Knights
Affiliation:
Department of Genetics, University of Cambridge
Janice R. Anderson
Affiliation:
Department of Histopathology, Addenbrooke's Hospital, Cambridge
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

An inherited exencephaly in the mouse is described, using embryos at 11–17 days gestation. The cephalic portion of the neural tube remains open on the dorsal surface, the bony vault of the brain fails to develop, and the tissues of the brain are exposed; the development of these tissues, which is somewhat variable, is described. There is strong evidence that the condition is due to a single recessive gene, xn, with full viability until birth. Penetrance is twice as high in females as in males, and it varies overall according to the genetic milieu studied, from 33% to 84%. These features, and the absence of pleiotropic effects and of genetic evidence of associated chromosomal anomalies, make its inheritance different from that of exencephalies so far described.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 2 , October 1978 , pp. 135 - 149
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Bonnevie, K. (1936). Pseudencephaly als spontane recessive (?) Mutation bei der Hausmaus. Skrifter utgitt ar det Norske videnskapsakademi i Oslo I. Math nat., Kl., no. 9, pp. 39.Google Scholar
Brown, K. S. & Harne, C. (1973). Recessive anencephalus in the oel strain of mice. Genetics 74, 231–232.Google Scholar
Brown, K. S. & Harne, L. C. (1974). Genetics of two traits: cleft palate and anencephalus in the oel strain of mice. Teratology 9, A–14.Google Scholar
Brown, K. S. (1977). Personal communication.Google Scholar
Carter, T. C. (1956). Genetics of Little and Bagg stock. Journal of Genetics 54, 311–325.CrossRefGoogle Scholar
Carter, T. C. (1959). Embryology of Blebby mice. Journal of Genetics 56, 401–433.CrossRefGoogle Scholar
Gleucksohn-Waelsch, S. (1961 a). Research News. Mouse News Letter 25, 12.Google Scholar
Gluecksohn-Waelsh, S. (1961 b). Developmental genetics of mammals. American Journal of Human Genetics 13, 113–121.Google Scholar
Grüneberg, H. (1952). The genetics of the mouse. Bibliographia Genetica 15, 138–144.Google Scholar
Geüneberg, H. (1954). Genetical studies on the skeleton of the mouse. VIII. Curly-tail. Journal of Genetics 52, 52–67.CrossRefGoogle Scholar
Grüneberg, H. (1963). The Pathology of Development. Oxford: Blackwell.Google Scholar
Kalter, H. (1968). Teratology of the Central Nervous System. Chicago and London: The University of Chicago Press.Google Scholar
Knights, P. (1972). Hydrancephaly. Mouse News Letter 47, 24.Google Scholar
Rugh, R. (1968). The Mouse: Its Reproduction and Development. Minneapolis: Burgess.Google Scholar
Searle, A. G. (1959). The incidence of anencephaly in a polytypic population. Annals of Human Genetics 23, 279–288.Google Scholar
Seller, M. J. (1968). Personal communication.Google Scholar
Snell, G. D., Bodemann, E. & Hollander, W. (1934). A translocation in the house mouse and its effects on development. Journal of Experimental Zoology 67, 93–104.CrossRefGoogle Scholar
Snell, G. D. & Picken, D. I. (1935). Abnormal development in the mouse caused by chromosome unbalance. Journal of Genetics 31, 213–235.CrossRefGoogle Scholar
Wallace, M. E. (1965). The Cambridge mouse cage. JATA (now Journal of the Institute of Animal Technicians) 16, 48–52.Google Scholar
Wallace, M. E. & Anderson, J. R. (1976). Exencephaly. Mouse News Letter 55, 10.Google Scholar
Wallace, M. E. & Knights, P. & Dye, A. O. (1976). Pilot study of the mutagencity of DDT in mice. Environmental Pollution 11, 217–222.Google Scholar