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Histocompatibility mutations in mice: chemical induction and linkage with the H-2 locus

Published online by Cambridge University Press:  14 April 2009

I. K. Egorov  and
Zinaida K. Blandova
I. K. Egorov
Affiliation:
Institute of General Genetics of the Academy of Sciences, Moscow, and Laboratory of Experimental Animals of the Academy of Medical Sciences, Moscow Region, U.S.S.R.
Zinaida K. Blandova
Affiliation:
Institute of General Genetics of the Academy of Sciences, Moscow, and Laboratory of Experimental Animals of the Academy of Medical Sciences, Moscow Region, U.S.S.R.
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Young mice of the strains A/Y and B10.D2 were repeatedly treated with diethylsulphate (DES) in different doses (36 to 1100 mg/kg). At the age of 9 weeks they were mated to females of the strains A. CA (‘A’ group) and C57BL/10Eg (‘D’ group) respectively. 2101 progeny of these matings were tested for histocompatibility by skin grafting. The spontaneous H-mutation rates were 6·96 × 10−4 per gamete in the A group and 9·6 × 10−4 per gamete in D group. In progeny of treated males the H-mutation rates were 0 in A group and 5·79 × 10−3 per gamete in D group, showing apparent effect of paternal DES treatment on mutation frequency in the last group. Two mutations of the H-2 locus were found, which together with the other three H-2 mutations published so far yielded a mutation rate of 5·18 × 10−4 per gamete. The mutation rate of the H-2 locus is higher than the expected rate per H-locus, indicating a great genetic complexity of H-2.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 2 , April 1972 , pp. 133 - 143
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Alderson, T. (1965). Chemically induced delayed germinal mutation in Drosophila. Nature, London 207, 164–167.Google Scholar
Bailey, D. W. (1966). Heritable histocompatibility changes: lysogeny in mice? Transplantation 4, 482–488.CrossRefGoogle ScholarPubMed
Bailey, D. W. (1968). The vastness and organization of the murine histocompatibility-gene system as inferred from mutational data. In Advances in Transplantation (ed. Dausset, J., Hamburger, J. and Mathe, G.), pp. 317–323. Copenhagen: Munksgaard.Google Scholar
Bailey, D. W. (1969). Communication. Mouse News Letter 41, 30.Google Scholar
Bailey, D. W. (1970). Analysis of a mutation at the histocompatibility-2 locus in mice. Abst.: Genetics 64, Supplement 2, 3.Google Scholar
Bailey, D. W. (1970 a). Four approaches to estimating number of histocompatibility loci. Transplantation Proceedings 2, 32–38.Google ScholarPubMed
Bailey, D. W. & Kohn, H. I. (1965). Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice. Genetical Research, Cambridge 6, 330–340.CrossRefGoogle ScholarPubMed
Counce, S., Smith, P., Barth, R. & Snell, G. D. (1956). Strong and weak histocompatibility gene differences in mice and their role in the rejection of homografts of tumors and skin. Annals of Surgery 144, 198–204.Google Scholar
Egorov, I. K. (1967). A mutation of the histocompatibility-2 locus in the mouse. Genetika, Moscow 3 (9), 136–144.Google Scholar
Egorov, I. K. & Blandova, Z. K. (1968). The genetic homogeneity of the inbred mice bred at the ‘Stolbovaya’ farm. II. Skin grafting tests. Genetika, Moscow 4 (12), 63–69.Google Scholar
Egorov, I. K. & Medvedev, N. N. (1966). Homozygosity of the C57BL/10ScSn, C57L/J, CC57BR and CC57W mouse strains as studied by the skin grafting method. Genetika, Moscow 2 (2), 130–136.Google Scholar
Epler, J. L. (1966). Ethyl methanesulfonate-induced lethals in Drosophila - frequency-dose relations and multiple mosaicism. Genetics 54, 31–36.CrossRefGoogle ScholarPubMed
Godfrey, J. & Searle, A. G. (1963). A search for histocompatibility difference between irradiated sublines of inbred mice. Genetical Research, Cambridge 4, 21–29.CrossRefGoogle Scholar
Jenkins, J. B. (1967 a). The induction of mosaic and complete dumpy mutants in Drosophila melanogaster with ethyl methanesulfonate. Mutation Research 4, 90–92.Google Scholar
Jenkins, J. B. (1967 b). Mutagenesis at a complex locus in Drosophila with the monofunctional alkylating agent, ethyl methanesulfonate. Genetics 57, 783–793.CrossRefGoogle Scholar
Kindred, B. (1963). Skin grafting between sublines of inbred strains of mice. Australian Journal of Biological Sciences 16, 863–868.CrossRefGoogle Scholar
Linder, O. E. A. & Klein, E. (1960). Skin and tumor grafting in coisogenic resistant lines of mice and their hybrids. Journal of National Cancer Institute 24, 707–720.Google Scholar
Malashenko, A. M. (1971). Sensitivity of mouse testis cells to the induction of dominant lethals by diethylsulphate. Genetika, Moscow 7 (1), 84–91.Google Scholar
Pelecanos, M. & Alderson, T. (1964). The mutagenic activity of diethylsulphate in Drosophila melanogaster. Mutation Research 1, 173–181.CrossRefGoogle Scholar
Schlager, G. & Dickie, M. (1967). Spontaneous mutations and mutation rates in the house mouse. Genetics 57, 319–330.Google Scholar
Snell, G. D. (1958). Histocompatibility genes of the mouse. II. Production and analysis of isogenic resistant lines. Journal of National Cancer Institute 21, 843–877.Google Scholar
Snell, G. D. (1960). Note on results of Linder and Klein with coisogenic resistant lines of mice. Journal of National Cancer Institute 25, 1191–1193.Google Scholar
Snell, G. D., Demant, P. & Cherry, M. (1971). Hemagglutination and cytotoxic studies of H-2. I. H-2.1 and related specificities in the EK crossover regions. Transplantation 11, 210–237.CrossRefGoogle ScholarPubMed
Snell, G. D. & Stimpfling, J. H. (1966). Genetics of tissue transplantation. In Biology of the Laboratory Mouse (ed. Green, E. L.), 2nd ed., pp. 457–491. New York: McGraw-Hill.Google Scholar
Staats, J. (1969). Inbred Strains of Mice, no. 6, pp. 1–126. Bar Habor.Google Scholar
Stimpfling, J. H. & Richardson, A. (1965). Recombination within the histocompatibility-2 locus of the mouse. Genetics 51, 831–846.CrossRefGoogle Scholar