Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-28T00:37:18.424Z Has data issue: false hasContentIssue false
  • English
  • Français

Heritability of cranium bifidum and spina bifida in the golden hamster

Published online by Cambridge University Press:  14 April 2009

A. M. Moffa  and
J. A. White
A. M. Moffa
Affiliation:
Department of Biology, West Virginia University, Morgantown W. Va. 26506, U.S.A.
J. A. White
Affiliation:
Box 1284, West Virginia University Medical School
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The heritability (h2) and frequency of the neural tube closure defects, cranium bifidum (CB) and spina bifida (SB), have been estimated for a population of 9-day-old hamster embryos through half-sibling analysis. The average frequency of the total affected embryos per litter is approximately 17% while the pooled estimate for h2 based on between sires and between dams within sires components was 4%. This value points to the importance of environmental factors in contributing to the variance in defect frequencies observed within this population.

Type
Short papers
Information
Genetics Research , Volume 34 , Issue 2 , October 1979 , pp. 189 - 194
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Bell, J. E. & Gosden, C. M. (1978). Central nervous system abnormalities – contrasting patterns in early and late pregnancy. Clinical Genetics 13, 387.Google Scholar
Boyer, C. C. (1953). Chronology of development for the golden hamster. Journal of Morphology 92, 1.Google Scholar
Carter, C. O. (1976). Genetics of common single malformations. British Medical Bulletin 32, 21.CrossRefGoogle ScholarPubMed
Carter, C. O. & Evans, K. (1973). Spina bifida and anencephaly in Greater London. Journal of Medical Genetics 10, 209.CrossRefGoogle ScholarPubMed
Cavalli-Sforza, L. L. & Bodmer, W. F. (1971). The Genetics of Human Populations. San Francisco: W. H. Freeman and Co.Google Scholar
Creasy, M. R. & Alberman, E. D. (1976). Congenital malformations of the central nervous system in spontaneous abortions. Journal of Medical Genetics 13, 9.CrossRefGoogle ScholarPubMed
Edwards, J. H. (1969). Familial predisposition in man. British Medical Bulletin 25, 58.Google Scholar
Elis, J. & DiPaolo, A. (1967). Aflatoxin B1 induction of malformations. Archives of Pathology 83, 53.Google Scholar
Elwood, J. H. (1972). Major CNS malformations notified in Northern Ireland 1964–8. Developmental Medicine and Child Neurology 14, 731.CrossRefGoogle Scholar
Falconer, D. S. (1965). The inheritance of liability to certain diseases, estimated from the incidence among relatives. Annals of Human Genetics 29, 51.CrossRefGoogle Scholar
Ferm, V. (1965). The rapid detection of teratogenic activity. Laboratory Investigations 14, 1500.Google ScholarPubMed
Fraser, F. C. (1976). The multifactorial/threshold concept uses and misuses. Teratology 14, 267.CrossRefGoogle ScholarPubMed
Janerich, D. T. (1973). Epidemic waves in the prevalence of anencephaly and spina bifida in New York State. Teratology 8, 253.CrossRefGoogle ScholarPubMed
Laurence, K. M., Carter, C. O. & David, P. A. (1968). Major CNS malformations in South Wales. I. Incidence, local variations and geographical factors. British Journal of Preventive and Social Medicine 22, 146.Google Scholar
Marin-Padilla, M. (1970). The closure of the neural tube in the Golden Hamster. Teratology 3, 39.Google Scholar
Nishimura, H. (1970). Incidence of malformations in abortions. Proceedings of the 3rd International Conference on Congenital Malformations (ed. F., Clark-Fraser and McKusick, V. A.). Amsterdam: Excerpta Medica.Google Scholar
Roberts, C. J. & Lloyd, S. (1973). Area differences in spontaneous abortion rates in South Wales and their relation to neural tube defect incidence. British Medical Journal 4, 20.Google Scholar
Robertson, A. & Lerner, I. M. (1949). The heritability of all-or-none traits: viability of poultry. Genetics 34, 395.CrossRefGoogle ScholarPubMed
Smith, C. (1970). Heritability of liability and concordance in monozygous twins. Annals of Human Genetics 23, 85.Google Scholar
Smith, C. (1971). Recurrence risks for multifactorial inheritance. American Journal of Human Genetics 23, 578.Google Scholar
Smithells, R. W., Sheppard, S. & Schorah, C. J. (1976). Vitamin deficiencies and neural tube defects. Archives of Disease in Childhood 51, 944.Google Scholar