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The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15

Published online by Cambridge University Press:  14 April 2009

Muriel T. Davisson ,
Thomas H. Roderick ,
Ellen C. Akeson ,
Norman L. Hawes  and
Hope O. Sweet
Muriel T. Davisson*
Affiliation:
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Thomas H. Roderick
Affiliation:
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Ellen C. Akeson
Affiliation:
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Norman L. Hawes
Affiliation:
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Hope O. Sweet
Affiliation:
The Jackson Laboratory, Bar Harbor, ME 04609, USA
*
* Corresponding author.
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Summary

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The mouse mutation hairy ears (Eh) originated in a neutron irradiation experiment at Oak Ridge National Laboratory. Subsequent linkage studies with Eh and other loci on Chr 15 suggested that it is associated with a chromosomal rearrangement that inhibits recombination since it shows tight linkage with several loci occupying the region extending from congenital goiter (cog) distal to caracul (ca). We report here (1) linkage experiments confirming this effect on recombination and (2) meiotic and mitotic cytological studies that confirm the presence of a chromosomal rearrangement. The data are consistent with the hypothesis of a paracentric inversion in the distal half of Chr 15. The effect of the inversion extends over a minimum of 30 cM, taking into account the genetic data and the cytologically determined chromosomal involvement extending to the region of the telomere.

Type
Research Article
Information
Genetics Research , Volume 56 , Issue 2-3 , October 1990 , pp. 167 - 178
Copyright
Copyright © Cambridge University Press 1990

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