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Growth and the distal tip of mouse chromosome 7

Published online by Cambridge University Press:  01 December 1998

C. F. GRAHAM ,
G. LUND  and
S. ZAINA
C. F. GRAHAM
Affiliation:
Zoology Department, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
G. LUND
Affiliation:
Zoology Department, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
S. ZAINA
Affiliation:
Zoology Department, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
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Abstract

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This review concerns the general problem of understanding growth control in the whole organism, starting with a saltatory change in size generated by a chromosome translocation or a mutation in a single gene. In particular, changes in insulin-like growth factor-II levels, by genetic and embryological manipulation, have major effects on wet weight size, but the intermediary events that link these levels to this measure of growth are uncertain. Thus it is currently impossible to eliminate any of the intermediary candidate processes that have been observed in model systems, including changed rates of apoptosis, cell multiplication, protein synthesis, capillary permeability and fluid transport.

Type
Research Article
Information
Genetics Research , Volume 72 , Issue 3 , December 1998 , pp. 247 - 253
Copyright
© 1998 Cambridge University Press