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The genetics of tasting in mice: III. Quinine

Published online by Cambridge University Press:  14 April 2009

Ian E. Lush
Ian E. Lush
Affiliation:
Department of Genetics and Biometry, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE

Summary

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Twenty-nine strains of mice were tested for their ability to taste a 0·8 mM solution of quinine sulphate. There were large strain differences, some strains (tasters) showing a strong aversion to the quinine and other strains (non-tasters) showing very little aversion. It was shown that the difference between strains 129/Sv and A2G is probably due to one gene. By using the CXB RI strains it was also shown that the difference between C57BL/6By and BALB/cBy is probably due to one gene. It is suggested that both differences may be due to the same gene, named Qui. In the progeny of a backcross involving both Soa and Qui there was evidence of an interaction between the genes which cannot be explained satisfactorily. Learning behaviour by the mice influenced their drinking habits, but this did not invalidate the results.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 2 , October 1984 , pp. 151 - 160
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Green, E. L. (1981). Genetics and Probability in Animal Breeding Experiments. London: Macmillan.CrossRefGoogle Scholar
Green, M. C. (1981). Genetic Variants and Strains of the Laboratory Mouse. Stuttgart: Fischer Verlag.Google Scholar
Lush, I. E. (1981). The genetics of tasting in mice. I. Sucrose octaacetate. Genetical Research 38, 93–95.CrossRefGoogle ScholarPubMed
Lush, I. E. (1982). The genetics of tasting in mice. II. Strychnine. Chemical Senses 7, 93–98.CrossRefGoogle Scholar
Warren, R. P. & Lewis, R. C. (1970). Taste polymorphism in mice involving a bitter sugar derivative. Nature 227, 77–78.CrossRefGoogle ScholarPubMed