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The genetics of some second chromosome melanotic tumour mutants of Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

John C. Sparrow
John C. Sparrow
Affiliation:
School of Biological Sciences, University of Sussex, Brighton
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Summary

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The genetic relationships of the available second chromosome melanotic tumour mutants in Drosophila melanogaster have been investigated. Complementation tests demonstrate the existence of new alleles of the tu bw locus and show that tu-W and tu-g are alleles. The data suggest that there is a minimum of three major gene loci on the second chromosome involved in tumorigenesis. A number of modifier genes were found which affect the penetrance of the major tumour genes analysed. These and the problems they cause in mapping the low penetrant tumour genes are discussed. It has not been possible to map tu-48a, tu- W and tu-g accurately, due largely to the presence of modifier genes. It appears that the genetic basis for melanotic tumour formation is complex.

Type
Research Article
Information
Genetics Research , Volume 23 , Issue 1 , February 1974 , pp. 13 - 21
Copyright
Copyright © Cambridge University Press 1974

References

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