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Genetics of MuBl and of a complement defect in inbred strains of mice

Published online by Cambridge University Press:  14 April 2009

B. Cinader ,
S. Dubiski  and
A. C. Wardlaw
B. Cinader
Affiliation:
Subdivision of Immunochemistry, Division of Biological Research, Ontario Cancer Institute, and Departments of Medical Biophysics and Pathological Chemistry, Connaught Medical Research Laboratories
S. Dubiski
Affiliation:
Department of Immunology, Toronto Western Hospital, and Department of Pathological Chemistry, Connaught Medical Research Laboratories
A. C. Wardlaw
Affiliation:
Connaught Medical Research Laboratories, University of Toronto, Toronto, Ontario, Canada
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A mouse antigen, MuB1, has been shown by the study of backcrosses to be inherited in a unifactorial dominant manner. Its inheritance is not linked with gamma globulin allotypes, but has been shown to be linked with the presence of the haemolytic complement system. The concentration of MuB1 in the serum of several inbred strains of mice showed sex-associated differences; however, the presence of MuBl did not depend on the sex of the parents or on the sex of the offspring. The inheritance of antibody responsiveness is discussed in terms of the inheritance of the antigen, MuB1.

Type
Research Article
Information
Genetics Research , Volume 7 , Issue 1 , February 1966 , pp. 32 - 43
Copyright
Copyright © Cambridge University Press 1966

References

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