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Genetics of host-controlled restriction and modification in Escherichia coli

Published online by Cambridge University Press:  14 April 2009

S. W. Glover  and
C. Colson
S. W. Glover
Affiliation:
Medical Research Council, Microbial Genetics Research Unit, Department of Molecular Biology, King's Buildings, West Mains Road, Edinburgh 9
C. Colson
Affiliation:
Institut Carnoy, University of Louvain, 24 Rue du Canal, Louvain, Belgium
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The sites of mutations affecting host-controlled modification (HCM) have been mapped in E. coli K and E. coli B by conjugation and transduction experiments between mutants. These mutations all map close to the serB locus on the opposite side to the marker thr. Non-parental HCM has been observed among colonies obtained from Pl transduction experiments between HCM mutants. Control experiments have shown that these non-parental recombinants can not be accounted for by reversion of either parent and must result from recombination between mutants. Several genetic models are suggested which could account for these recombinants and an attempt is made to distinguish between various models by testing for complementation between mutants in a zygotic induction complementation test.

Type
Research Article
Information
Genetics Research , Volume 13 , Issue 2 , April 1969 , pp. 227 - 240
Copyright
Copyright © Cambridge University Press 1969

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