Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-28T00:13:20.807Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetical studies on the skeleton of the mouse XXVI. Pintail*

Published online by Cambridge University Press:  14 April 2009

R. J. Berry
R. J. Berry
Affiliation:
Medical Research Council Experimental Genetics Research Unit, University College London
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The gene for Pintail (symbol Pt) shows no dominance. Heterozygotes are viable and fertile; many homozygotes die early in life, but the survivors appear to breed normally. Pt reinforces the effects of Sd and T on the tail; there is no evidence for interaction between Pt and + /vt.

2. The gene produces a shortening of the tail, but the most marked effect on the adult is in the great reduction of the nucleus pulposus of the intervertebral discs, which may lead to tail kinks in some animals.

3. Pintail embryos can be recognized from the eleventh day stage of development onwards by the possession of a much smaller notochord than normal. This reduced notochord is the result of a reduced rate of cell division which first manifests itself in 10-day embryos. Perhaps this reduced rate is the result of altered relations of the notochord with tail-gut and neural tube in 10-day embryos.

Type
Research Article
Information
Genetics Research , Volume 1 , Issue 3 , November 1960 , pp. 439 - 451
Copyright
Copyright © Cambridge University Press 1960

References

REFERENCES

Abercrombie, M. (1946). Estimation of nuclear proportions from microtome sections. Anat. Rec. 94, 239–247.CrossRefGoogle Scholar
Berry, R. J. (1960). A genetically controlled degeneration of the nucleus pulposus in the. mouse. (In preparation.)Google Scholar
Deol, M. S. & Truslove, G. M. (1957). Genetical studies on the skeleton of the mouse. XX. Maternal physiology and variation in the skeleton of C57BL mice. J. Genet. 55, 288–312.CrossRefGoogle Scholar
Grüneberg, H. (1943). The development of some external features in mouse embryos. J. Hered. 30, 88–92.Google Scholar
Grüneberg, H. (1953 a). Genetical studies on the skeleton of the mouse. VII. Congenital hydrocephalus. J. Genet. 51, 327–358.CrossRefGoogle Scholar
Grünebebg, H. (1953 b). Genetical studies on the skeleton of the mouse. VI. Danforth's short-tail. J. Genet. 51, 317–326.CrossRefGoogle Scholar
Grüneberg, H. (1955). Genetical studies on the skeleton of the mouse. XV. Relations between major and minor variants. J. Genet. 53, 515–535.CrossRefGoogle Scholar
Grüneberg, H. (1956). A ventral ectodermal ridge of the tail in mouse embryos. Nature, Lond., 177, 787–788.CrossRefGoogle ScholarPubMed
Grunebebg, H. (1958 a). Genetical studies on the skeleton of the mouse. XXIII. The development of Brachyury and Anury. J. Embryol. exp. Morph. 6, 424–443.Google Scholar
Grüneberg, H. (1958 b). Genetical studies on the skeleton of the mouse. XXII. The development of Danforth's short-tail. J. Embryol. exp. Morph. 6, 124–148.Google ScholarPubMed
Hollander, W. F. (1951). Inherited persistent cloaca in adult mice. Anat. Rec. 111, 477 (Abstr.)Google Scholar
Hollander, W. F. & Strong, L. C. (1951). Pintail, a dominant mutation linked with brown in the house mouse. J. Hered. 42, 179–182.CrossRefGoogle Scholar
Noback, G. J. (1916). The use of the Van Wijhe method for the staining of the cartilaginous skeleton. Anat. Rec. 11, 292–294.Google Scholar
Peterfi, T. (1921). Eine beschleunigte Celloidin-Paraffineinbettung mit Nelkenöl oder Methylbenzoatcelloidin. Z. wiss. Mikr. 38, 342–345.Google Scholar
Theiler, K. (1951). Die Entwicklung der Zwischenwirbelscheiben bei der Short-Danforth-Maus. Rev. suisse Zool. 58, 484–488.Google Scholar