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Genetic variance and fixation probabilities at quantitative trait loci in mutation-selection balance

Published online by Cambridge University Press:  14 April 2009

Peter D. Keightley
Peter D. Keightley
Affiliation:
Institute of Cell Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
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Summary

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Genetic variance and fixation probabilities are evaluated for a model of a quantitative trait at a balance between mutation, selection and drift in which many alleles can segregate at each locus. If the distribution of effects of new mutant alleles is such that mutations are unconditionally deleterious, as might be the case in natural populations, genetic variance maintained is proportional to the number of mutations occurring in the genome per generation, but is independent of the number of loci at which they appear. If selectively advantageous alleles can occur these tend to interfere to a greater extent with each others' fixation and increasing mutation rate leads to a decrease in the genetic variance as a fraction of the variance maintained in the absence of selection. Fixation probabilities of new mutant alleles approach that for neutral alleles with increasing mutation rate at a locus irrespective of their effects on fitness. The additive genetic variance contributed by the locus may appear to be ‘decoupled’ from the fixation rate of mutant alleles.

Type
Research Article
Information
Genetics Research , Volume 58 , Issue 2 , October 1991 , pp. 139 - 144
Copyright
Copyright © Cambridge University Press 1991

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