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Genetic loads at a polymorphic locus which is maintained by frequency-dependent selection*

Published online by Cambridge University Press:  14 April 2009

Motoo Kimura  and
Tomoko Ohta
Motoo Kimura
Affiliation:
National Institute of Genetics, Mishima, Japan
Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima, Japan
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Summary

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If a polymorphic locus is maintained in finite populations by frequency-dependent selection with selective neutrality at equilibrium, it is generally accompanied by two genetic loads, i.e. the dysmetric and the drift loads. The former arises because the fitness of the population may not be at a maximum at the equilibrium gene frequency and the latter because genetic drift in small populations displaces the gene frequency from its equilibrium value.

In some simple models of frequency-dependent selection considered, the drift load is independent of selection coefficients and is approximately equal to (n−1)/(2Ne), where n is the number of alleles and Ne is the effective population size.

Type
Research Article
Information
Genetics Research , Volume 16 , Issue 2 , October 1970 , pp. 145 - 150
Copyright
Copyright © Cambridge University Press 1970

References

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