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Genetic evidence for restriction targets in the DNA of phages λ and φ 80

Published online by Cambridge University Press:  14 April 2009

Naomi C. Franklin  and
William F. Dove
Naomi C. Franklin
Affiliation:
Department of Biological Sciences, Stanford University, Stanford, California, U.S.A.94305
William F. Dove
Affiliation:
McArdle Laboratory, University of Wisconsin, Madison, Wisconsin, U.S.A.53706
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Temperate phages φ 80 and λ grown in E. coli strain C differ markedly in the degree to which they are restricted by E. coli strain K. The basis of this difference is subject to genetic recombination and deletion. The loss of restriction sensitivity by deletion shows that sensitivity is determined by loci in the phage genome. These loci are interpreted to be targets of the restriction mechanism, in agreement with previous biochemical evidence.

Type
Research Article
Information
Genetics Research , Volume 14 , Issue 2 , October 1969 , pp. 151 - 157
Copyright
Copyright © Cambridge University Press 1969

References

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