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Genetic differences between substrains of the inbred mouse strain 101 and designation of a new strain 102

Published online by Cambridge University Press:  14 April 2009

John D. West ,
Mary F. Lyon ,
Josephine Peters  and
Paul B. Selby
John D. West
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 0RD, England
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 0RD, England
Josephine Peters
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 0RD, England
Paul B. Selby
Affiliation:
Biology Division, Oak Ridge National Laboratory, PO Box Y, Oak Ridge, Tennessee 37830, U.S.A.

Summary

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Genetic polymorphisms revealed two distinct substrains of the inbred strain 101. One group included substrains 101*/Rl, 101/H and 101/HOxe; the other group comprised 101/El and 101/Sl. The two groups differed at 5 of the 8 genetic loci tested. The accompanying paper (Evans, Burtenshaw & Adler, 1985) shows that the two groups also differ for several chromosome polymorphisms. We suggest that genetic contamination occurred during the derivation of 101/El from 101/Rl and was already present in 101/El when 101/Sl was produced from this substrain. We further propose that these substrains be renamed 102/El and 102/Sl respectively.

Type
Short Papers
Information
Genetics Research , Volume 46 , Issue 3 , December 1985 , pp. 349 - 352
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Evans, E. P., Burtenshaw, M. D. & Adler, I. D. (1985). Chromosome differences between substrains of the inbred 101 mouse strain. Genetical Research 46, 353–356.CrossRefGoogle ScholarPubMed
Favor, J. (1983). A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutation Research 110, 367–382.CrossRefGoogle ScholarPubMed
Kratochvilova, J. (1981). Dominant cataract mutations detected in offspring of gamma-irradiated male mice. Journal of Heredity 72, 302–307.CrossRefGoogle ScholarPubMed
West, J. D. & Fisher, G. (1985). Inherited cataracts in inbred mice. Genetical Research 46, 45–56.CrossRefGoogle ScholarPubMed
West, J. D., Peters, J. & Lyon, M. F. (1984). Genetic differences between two substrains of the inbred 101 mouse strain. Genetical Research 44, 343–346.CrossRefGoogle ScholarPubMed