Hostname: page-component-745bb68f8f-kw2vx Total loading time: 0 Render date: 2025-01-12T21:29:56.387Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic basis of susceptibility to splenic lipofuscinosis in mice

Published online by Cambridge University Press:  14 April 2009

D. N. Crichton  and
J. G. M. Shire
D. N. Crichton
Affiliation:
MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh EH4 2XU, Scotland
J. G. M. Shire
Affiliation:
Institute of Genetics, University of Glasgow, Glasgow G11 5JS, Scotland Department of Biology, University of Essex, Colchester CO4 3SQ, England
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Spleens with black pigment in them were found in 4–57% of mice from 17 stocks, all sublines of C57BL or with significant C57BL ancestry. Splenic lipofuscinosis was absent from 16 stocks, including three C57BL/6By × BALB/cBy recombinant - inbred lines. Progeny testing showed all C57BL/6J mice to be equally likely to develop black spleens. The penetrance of lipofuscinosis differed between sublines but not between the sexes or between laboratories. Susceptibility to lipofuscinosis showed dominant, autosomal, inheritance in F1 hybrids. Observations on backcrosses and on recombinant inbred lines and their intercrosses indicated the existence of two genetic factors. Splenic lipofuscinosis was prevented either by a deficiency of melanin or by homozygosity for a non-C57BL allele close to the c-p region of chromosome 7. The presence of a C57BL allele at a locus on another chromosome is necessary for lipofuscinosis to occur.

Type
Research Article
Information
Genetics Research , Volume 39 , Issue 3 , June 1982 , pp. 275 - 285
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Bailey, D. W. (1971). Recombinant inbred strains. An aid to finding the identity, linkage and function of histocompatibility and other genes. Transplantation 11, 325–327.CrossRefGoogle ScholarPubMed
Bailey, D. W. (1978). Sources of subline divergence and their relative importance for sublines of six major inbred strains. In Origins of Inbred Mice (ed. Morse, H. C.), pp. 197–215. New York: Academic Press.CrossRefGoogle Scholar
Blackwell, J. M. (1981). The role of the house mouse in disease and zoonoses. In Symposia of the Zoological Society of London, 47, Biology of the House Mouse, (ed. Berry, R. J.), pp. 591–616. London: Academic Press.Google Scholar
Brandt, E. J., Elliott, R. W. & Swank, R. T. (1975). Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice. Journal of Cell Biology 67, 774–778.CrossRefGoogle ScholarPubMed
Crichton, D. N., Busuttil, A., Price, W. H., Robertson, J. & Swinton, J. (1978 a). Lipofuscin deposition in the spleens of mice. Journal of the Institute of Animal Technicians 29, 1–6.Google Scholar
Crichton, D. N., Busuttil, A. & Price, W. H. (1978 b). Splenic lipofuscinosis in mice. Journal of Pathology 126, 113–120.CrossRefGoogle ScholarPubMed
Crichton, D. N., Busuttil, A. & Ross, A. (1980). An ultrastructural study of murine splenic lipofuscinosis. Journal of Ultrastructural Research 72, 130–140.CrossRefGoogle ScholarPubMed
De Duve, C. & Wattiaux, R. (1966). Functions of lysosomes. Annual Review of Physiology 28, 435–192.CrossRefGoogle ScholarPubMed
Doering, C. H., Shire, J. G. M., Kessler, S. & Clayton, R. B. (1972). Cholesterol ester concentration and corticosterone production in adrenals of the C57BL/10 and DBA/2 strains in relation to adrenal lipid depletion. Endocrinology 90, 93–101.CrossRefGoogle ScholarPubMed
Engelking, L. R. & Gronwall, R. (1979). Bile acid clearance in sheep with hereditary hyperbilirubinemia. American Journal of Veterinary Research 40, 1277–1280.Google ScholarPubMed
Festing, M. F. W. (1979). Inbred Strains in Biomedical Research London: Macmillan Press Ltd.CrossRefGoogle Scholar
Gibb, S., Hakansson, E. M., Lundin, L. G. & Shire, J. G. M. (1981). Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse. Genetical Research 37, 95–103.CrossRefGoogle Scholar
Hakansson, E. M. &, Lundin, L. G. (1977). The effect ofacoat colour locus on kidney lysosomal glycosidases in the house mouse. Biochemical Genetics 15, 75–85.CrossRefGoogle ScholarPubMed
Levine, S. & Treiman, D. M. (1964). Differential plasma corticosterone response to stress in four inbred strains of mice. Endocrinology 75, 142–144.CrossRefGoogle ScholarPubMed
Lundin, L. G. (1979). Evolutionary conservation of large chromosomal segments reflected in mammalian gene maps. Clinical Genetics 16, 72–81.CrossRefGoogle ScholarPubMed
Miguel, F., Oho, J., Bensch, K. G. & Johnson, J. E. (1977). pp. 133–182 in Free Radicals in Biology vol. 3 (ed. Pryor, W. A.), New York: Academic Press.CrossRefGoogle Scholar
Novak, E. T. & Swank, R. T. (1979). Lysosomal dysfunctions associated with mutations at mouse pigment genes. Genetics 92, 189–204.CrossRefGoogle ScholarPubMed
Oliverio, A. (1979). Uses of recombinant inbred lines. pp. 197–218 in Quantitative Genetic Variation (ed. Thompson, J. N. and Thoday, J. M.), New York: Academic Press.CrossRefGoogle Scholar
Pearse, A. G. E. (1972). Histochemistry, Theoretical and Applied, 3rd edn, vol. 2. Edinburgh: Churchill Livingstone.Google Scholar
Russell, E. S. (1979). Hereditary anemias of the mouse: a review for geneticists. Advances in Genetics 20, 358–459.Google Scholar
Shire, J. G. M. (1981). Genes and hormones in mice. In Symposia of the Zoological Society of London 47, Biology of the House Mouse (ed. Berry, R. J.), pp. 547–574. London: Academic Press.Google Scholar
Swank, R. T. & Bailey, E. W. (1973). Recombinant inbred lines: value in the genetic analysis of biochemical variants. Science 181, 1249–1251.CrossRefGoogle ScholarPubMed
Swartz, H. M., Sarna, T. & Varma, R. R. (1979). On the nature and excretion of the hepatic pigment in the Dubin-Johnson syndrome. Gastroenterology 76, 958–964.CrossRefGoogle ScholarPubMed