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Genetic analysis of the mutation Female-lethal in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Terri Marshall  and
J. R. S. Whittle
Terri Marshall
Affiliation:
School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, Sussex
J. R. S. Whittle
Affiliation:
School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, Sussex
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A genetic analysis was made of the Female-lethal (Fl) locus of Drosophila melanogaster. This is an X-linked mutation which causes lethality only in females. Other alleles do not complement Fl and are either lethal or sterile when homozygous in females. Complementation studies on Fl alleles demonstrate that there is no simple ranking of these alleles in terms of severity of phenotypic effect. Dosage manipulation of Fl alleles indicates that the sex-specificity is not a consequence of gene dosage effects. Viability studies on males carrying Fl alleles show that Fl alleles have no effect on viability regardless of the presence or absence of a Y chromosome. The Fl locus is therefore sex-specific. The hypothesis that Fl+ is involved in the establishment of imaginal phenotypic sex cannot be substantiated on the basis of experiments utilizing sex-change mutations.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 2 , October 1978 , pp. 103 - 111
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Brown, E. H. & King, R. C. (1961). Studies on the expression of the transformer gene of D. melanogaster. Genetics 46, 143–156.Google Scholar
Colainne, J. J. & Bell, A. E. (1968). The effect of the doublesex (dsx) mutant on the action of daughterlesa (da) in D. melanogaster. Drosophila Information Service 43, 155.Google Scholar
Colainne, J. J. & Bell, A. E. (1970). Sonless, a sex-ratio anomaly in D. melanogaster resulting from a gene–cytoplasm interaction. Genetics 65, 619–625.Google Scholar
Colainne, J. J. & Bell, A. E. (1972). The relative influence of sex of progeny on lethal expression of sonless gene in D. melanogaster. Genetics 72, 293–296.Google Scholar
Fukunaga, A., Tanaka, A. & Oishi, K. (1975). Maleless – a recessive autosomal mutant of D. melanogaster that specifically kills male zygotes. Genetics 81, 135–141.CrossRefGoogle ScholarPubMed
Lefevre, G. & Johnson, T. K. (1973). Evidence for a sex-linked haplo-inviable locus in the cut-singed region of D. melanogaster. Genetics 74, 633–645.CrossRefGoogle Scholar
Lindsley, D. L., Edington, C. W. & Von Halle, E. S. (1960). Sex-linked recessive lethals in Drosophila whose expression is suppressed by the Y chromosome. Genetics 45, 1649–1670.Google Scholar
Lindsley, D. E. & Grell, E. H. (1968). Genetic Variations of Drosophila melanogaster. Washington: Carnegie Institution Press.Google Scholar
Marshall, M. T. (1977). Developmental genetics of the mutation Female-lethal in Drosophila melanogaster. D.Phil, thesis, University of Sussex.Google Scholar
Miyamoto, C. & Oishi, K. (1975). Effects of SR spirochaete infection on D. melanogaster carrying intersex genes. Genetics 79, 55–61.Google Scholar
Muller, H. J. (1932). Further studies on the nature and causes of gene mutations. Proc. 6th Int. Congr. Genet. Ithaca 1, 213–255.Google Scholar
Muller, H. J. & Zimmering, S. (1960). A sex-linked lethal without evident effect in Drosophila males but partially dominant in females. Genetics 45 (Abs), 1001–1002.Google Scholar
Sakaguchi, B. & Poulson, D. F. (1963). Interspecific transfer of the sex-ratio condition from D. willistoni to D. melanogaster. Genetics 48, 841–861.Google Scholar
Sandler, L. (1970). The regulation of sex-chromosome heterochromatic activity by an autosomal gene in D. melanogaster. Genetics 64, 481–493.CrossRefGoogle Scholar
Sandler, L. (1972). On the genetic control of genes located in the sex chromosome heterochromatin of D. melanogaster. Genetics 70, 261–274.Google Scholar
Sturtevant, A. H. (1945). A gene in D. melanogaster that transforms females into males. Genetics 30, 297–299.Google Scholar
Zimmering, S. & Muller, H. J. (1961). Studies on the action of the dominant xyiFemale lethal Fl and of a seemingly less extreme allele Fls. Drosophila Information Service 35, 105.Google Scholar