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Genetic analysis of physiological homeostasis: glomerular filtration rate following saline loading in mice

Published online by Cambridge University Press:  14 April 2009

J. Stewart  and
S. Mowbray
J. Stewart
Affiliation:
Department of Genetics, Milton Road, Cambridge, England
S. Mowbray
Affiliation:
Department of Genetics, Milton Road, Cambridge, England
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Summary

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Saline loading caused an increase in glomerular filtration rate in RAP mice but not in CBA mice. On the basis of progeny testing of F 2 hybrids, backcrosses to CBA, and inbred lines derived from backcrosses to RAP, it was concluded that the difference between the strains RAP and CBA was probably largely accounted for by a single gene locus. The use of this gene in physiological investigations of the control of glomerular filtration rate is suggested.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 1 , February 1972 , pp. 61 - 72
Copyright
Copyright © Cambridge University Press 1972

References

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