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Gene-environment interactions of the eyeless mutant in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

David M. Hunt  and
Barrie Burnet
David M. Hunt
Affiliation:
Department of Genetics, University of Sheffield, England
Barrie Burnet
Affiliation:
Department of Genetics, University of Sheffield, England
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A method is described for quantifying the phenotypic expression of eyeless using gauged estimates of the mean and standard deviation of the distribution of facet numbers.

Gene-environment interactions of four eyeless alleles ey, ey2ey4 and eyK are compared in different genetic backgrounds and on a standardized Pacific background. The original strains differ in mean phenotypic value and in direction of response to variations in the ribonucleic acid content of the larval culture medium, whereas the four Pacific strains are more concordant. Consequently these differences are in part attributable to modifier genes present in the different genetic backgrounds of the original strains. Modifier genes also influence the periods in development at which eyeless is sensitive to nutritional treatments.

On the standardized Pacific background deficiencies of cholesterol cause an increase, whereas deficiencies of RNA or thiamine cause a decrease in the expressvity of all four eyeless alleles, but non-identity of their interaction profiles over an array of different suboptimal environments suggest that they may form a group of heteroalleles.

Type
Research Article
Information
Genetics Research , Volume 13 , Issue 3 , June 1969 , pp. 251 - 265
Copyright
Copyright © Cambridge University Press 1969

References

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