Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-08T05:21:39.907Z Has data issue: false hasContentIssue false

Further observations on the hairpin-tail (Thp) mutation in the mouse

Published online by Cambridge University Press:  14 April 2009

D. R. Johnson
Affiliation:
Department of Animal Genetics, University College London
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The hairpin-tail allele (Thp) of brachyury (T) on chromosome 17 of the mouse is unique in that the phenotype of heterozygous offspring depends on which parent contributed the Thp.The present paper offers formal proof of this fact using the th2 allele of T as a marker, and discusses possible modes of action of the hairpin allele.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Beatty, R. A. (1970). The genetics of the mammalian gamete. Biological Reviews 45, 73120.CrossRefGoogle ScholarPubMed
Braden, A. W. H. (1957). Variation between strains in the incidence of various abnormalities of egg maturation and fertilization in the mouse. Journal of Genetics 55, 476486.CrossRefGoogle Scholar
Castro-Sierra, E. & Ohno, S. (1968). Allelic inhibition of the autosomally inherited gene locus for alcohol dehydrogenase in chieken-quail hybrids. Biochemical Genetics 1, 323335.CrossRefGoogle ScholarPubMed
Chapman, V. M., Whitten, W. K. & Ruddle, F. H. (1971). Expression of paternal glucose phosphate isomerase -1 (Gpi-1) in preimplantation stages of mouse embryos. Developmental Biology 26, 153158.CrossRefGoogle ScholarPubMed
Dunn, L. C. (1964). Abnormalities associated with a chromosome region in the mouse. Science 144, 260263.CrossRefGoogle ScholarPubMed
Epstein, C. J. (1972). Expression of the mammalian X chromosome before and after fertilization. Science 175, 1467.CrossRefGoogle ScholarPubMed
Epstein, C. J., Weston, J. A., Whitten, W. K. & Russell, E. S. (1972). The expression of the isocitrate dehydrogenase locus (Id-1) during mouse embryogenesis. Developmental Biology 27, 430433.CrossRefGoogle Scholar
Evans, E. P., Breckon, G. & Ford, C. E. (1964). An air drying method for meiotic preparations from mammalian testes. Cytogenetics 3, 289292,CrossRefGoogle ScholarPubMed
Gluecksohn-Waelsch, S. & Ericsson, R. P. (1970). The T-locus of the mouse: implications for mechanisms of development. Current Topics in Developmental Biology 5, 281316.CrossRefGoogle ScholarPubMed
Johnson, D. R. (1974). Hairpin-tail: a case of post reductional gene action in the mouse egg? Genetics 76, 795805.CrossRefGoogle ScholarPubMed
Kumineck, K. (1959). Die Morphologie den unteren Wirbelsäule bei einen spontanen Kurzschwanzmutationen den Hausmasu. Biologisches Zentralblatt 78, 719758.Google Scholar
Kumineck, K. (1960). Die Genetick einen neu aufgetratenen spontanen Kurzschwanmutationen bei der Hausmaus. Zeischrift für Vererbungslehre 91, 182200.Google Scholar
Lyon, M. F. (1959). A new dominant T-allele in the house mouse. Journal of Heredity 19, 301312.CrossRefGoogle Scholar
Lyon, M. F. & Meredith, R. (1964). Investigations of the nature of t alleles in the mouse. I. Genetic analysis of a series of mutations derived from a lethal allele. Heredity 19, 301312.CrossRefGoogle ScholarPubMed
Ohno, S., Stenius, C., Christian, L. C. & Harris, C. (1968). Synchronous activation of both parental alleles at the 6-PGD locus of the Japanese quail. Biochemical Genetics 2, 197204.CrossRefGoogle Scholar
Ohno, S., Christian, L. C., Castro-Sierra, E. & Muramato, J. (1969). Developmental genetics of the alcohol dehydrogenase locus of the Japanese quail. Biochemical Genetics 2, 361369.CrossRefGoogle ScholarPubMed
Searle, A. G. (1966). Curtailed, a new dominant T-allele in the house mouse. Genetical Research 7, 8695.CrossRefGoogle ScholarPubMed
Thorndike, J., Trigg, M. J., Stockert, R., Gluecksohn-Waelsch, S. & Cori, C. F. (1973). Multiple biochemical effects of a series of X-ray induced mutations at the albino locus in the mouse. Biochemical Genetics 9, 2539.CrossRefGoogle ScholarPubMed
Trigg, M. J. & Gluecksohn-Waelsch, S. (1973). Ultrastructural basis of biochemical effects in a series of lethal alleles in the mouse. Journal of Cell Biology 58, 549563.CrossRefGoogle Scholar